Objectives: To determine the frequency and timing of B-type natriuretic peptide (BNP) and unbound free fatty acid (FFAu) elevation after percutaneous coronary intervention (PCI).
Design And Methods: Blood samples were collected from 55 patients undergoing PCI within 1 hour prior to PCI, immediately after PCI, 6 hours and 18-24 hours after PCI, and were analyzed for BNP and FFAu.
Results: There was a trend toward a rise in BNP levels at 18-24 hours post-PCI (65 vs. 45 pg/ml; p = 0.056). FFAu levels rose immediately after PCI and returned to baseline by 6 hours postprocedure (2.0 nM pre-PCI, 6.4 nM immediately post-PCI, 1.9 nM 6 hours post-PCI, and 2.2 nM 18-24 hours post-PCI; p < 0.0001). BNP and FFAu levels were elevated post-PCI in 17% and 82% of cases.
Conclusions: PCI using short inflation times and coronary stenting are associated with a trend toward increased BNP levels at 18-24 hours post-PCI and a transient significant rise in FFAu levels.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Drug Development.
Alzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA.
Background: Apolipoprotein E4 (apoE4) has been identified as the major genetic risk factor for late onset Alzheimer's disease (AD). Our lab has demonstrated that chronic administration of Aβ12-28P, a synthetic peptide that blocks apoE4/Aβ binding, in middle-aged transgenic AD mice significantly ameliorates pathology progression, resulting in reduced Aβ plaques deposition and cerebral amyloid angiopathy (CAA) along with improved memory and cognition. However, whether blocking apoE4/Aβ interaction by Aβ12-28P also has an ameliorating effect on the neuronal and cognitive function of old AD mice where Aβ pathology has been extensively developed remains unknown.
View Article and Find Full Text PDFComparison of 2-pool and 3-pool digestion kinetics model predictions of neutral detergent fiber digestibility of forages from commercially available data.
J Dairy Sci
December 2024
U.S. Dairy Forage Research Center, USDA-ARS, Madison, WI. Electronic address:
Sizes and rates of potentially digestible (B) and undegradable (C) pools of amylase-treated neutral detergent fiber (aNDF) are used to predict ruminal aNDF digestibility (aNDFD%) in widely used dairy cattle diet formulation programs. An exponential 3-pool model (3P) has been suggested for estimating digestion kinetic parameters for this purpose, however, the approach has not been compared with using a simpler exponential 2-pool model (2P), nor with using commercial laboratory (lab) data on which application would rely, nor on model impact on predictions of aNDFD% which is the aim of their application. Our objective was to determine whether 2P or 3P most accurately and efficiently characterizes aNDF digestion kinetics and if the models differed in predicted aNDFD%.
View Article and Find Full Text PDFSputum culture contamination and associated characteristics in a diagnostic clinical trial, Papua New Guinea.
Public Health Action
December 2024
Burnet Institute, Melbourne, Australia.
Setting: Papua New Guinea is a high-burden multidrug-resistant TB (MDR/RR-TB) country that reports low rates of bacteriological confirmation. Sputum drug susceptibility testing for second-line drugs is important. Access to culture is limited.
View Article and Find Full Text PDFThe determination of endogenous steroids in hair and fur: A systematic review of methodologies.
J Steroid Biochem Mol Biol
February 2025
Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland; School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address:
Background: Endogenous steroid hormone assessment is essential for clinical practice. These hormones are typically measured in blood. More recently, measurement of steroids in hair samples has been gaining in popularity, so we have reviewed the methodologies used for this to-date.
View Article and Find Full Text PDFProfessional reintegration of stroke survivors and their mental health, quality of life and community integration.
Qual Life Res
December 2024
São João de Deus School of Nursing, University of Évora, Évora, Portugal.
Article Synopsis
- The study aimed to explore the relationship between professional reintegration (return to work) and mental health, quality of life, and community reintegration in stroke survivors 18-24 months post-stroke.
- A survey of 553 stroke survivors revealed that 56.6% had returned to work, and this return was positively linked with better community integration but negatively associated with depressive symptoms.
- The findings suggest that while returning to work can improve community ties, it may also point to mental health challenges, indicating a need for further research on the obstacles stroke survivors face in reintegrating into the workforce.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!