The in vitro effect of major immunosuppressive agents on the CD3-TCR complex expression on T cells was studied. Cyclosporine and azathioprine caused a marked diminution of alpha/beta, but not gamma/delta and CD3 chains detectability. Prednisolone effect was less manifested. Our data suggest that the reported decrease in alpha/beta chains expression on T cells from renal allograft recipients may be caused by post-transplant immunosuppression.
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