Data concerning the concentration of dioxins (PCDD/PCDFs), polychlorinated biphenyls (PCBs), metals, metalloids, pesticides and antimicrobials residues are reported for the edible portion of Australian wild and farmed southern bluefin tuna (Thunnus maccoyii). In 2004 wild caught (n=5) and farmed (n=26) southern bluefin tuna (SBT) were collected. The mean concentration of total mercury on a fresh weight (fw) basis was 0.34 mg/kg in wild SBT and 0.31 mg/kg in farmed SBT. Concentrations of dioxins (PCDD/PCDFs) and polychlorinated biphenyls (PCBs) found in wild SBT were extremely low. The mean concentration (fw) of the sum of PCDD/PCDFs and the dioxin-like PCBs was 0.27 pg TEQ/g in wild SBT and 0.61 pg TEQ/g in farmed SBT. Mean PCB total concentration (fw basis) was 0.47 ng/g in wild SBT and 6.60 ng/g in farmed SBT. No detectable residues of any pesticide or antimicrobial compounds were found. All residues detected were within regulatory limits set by the Japanese Competent Authority, the Ministry of Health, Labour and Welfare (MHLW) and the Australian Competent Authority, Food Standards Australia New Zealand (FSANZ). The need for harmonisation of international product integrity procedures for bluefin tunas in international trade is highlighted.
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http://dx.doi.org/10.1016/j.chemosphere.2008.02.029 | DOI Listing |
Pharmaceutics
September 2024
Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Curr Issues Mol Biol
August 2024
Department of Obstetrics and Gynecology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
Cells
August 2024
Division of Bioinformatics, Institute of Biochemistry, FAU, 91054 Erlangen, Germany.
Herpesviral protein kinases, such as the therapy-relevant pUL97 of human cytomegalovirus (HCMV), are important for viral replication efficiency as well as pathogenesis, and represent key antiviral drug targets. HCMV pUL97 is a viral cyclin-dependent kinase (CDK) ortholog, as it shares functional and structural properties with human CDKs. Recently, the formation of vCDK/pUL97-cyclin complexes and the phosphorylation of a variety of viral and cellular substrate proteins has been demonstrated.
View Article and Find Full Text PDFCancers (Basel)
June 2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of the Ministry of Health of Russia, Bldg. 4, Oparina Street, 117513 Moscow, Russia.
According to recent reports, ovarian serous borderline tumor (SBT) harboring the V600E mutation is associated with a lower risk of progression to low-grade serous carcinoma. Preliminary observations suggest that there may be an association between eosinophilic cells (ECs) and the above-mentioned mutation, so this study aimed to evaluate interobserver reproducibility for assessing ECs. Forty-two samples of SBTs were analyzed for ECs with abundant eosinophilic cytoplasm.
View Article and Find Full Text PDFPharmaceutics
November 2023
Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Despite the availability of currently approved antiviral drugs, infections with human cytomegalovirus (HCMV) still cause clinically challenging, sometimes life-threatening situations. There is an urgent need for enhanced anti-HCMV drugs that offer improved efficacy, reduced dosages and options for long-term treatment without risk of the development of viral drug resistance. Recently, we reported the pronounced anti-HCMV efficacy of pharmacological inhibitors of cyclin-dependent kinases (CDKs), in particular, the potential of utilizing drug synergies upon combination treatment with inhibitors of host CDKs and the viral CDK-like kinase pUL97 (vCDK/pUL97).
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