Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/cr078246a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Depolarization of mouse DRG neurons by GABA does not translate into acute pain or hyperalgesia in healthy human volunteers.
PLoS One
August 2024
Experimental Pain Research, MCTN, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
The majority of somatosensory DRG neurons express GABAA receptors (GABAAR) and depolarise in response to its activation based on the high intracellular chloride concentration maintained by the Na-K-Cl cotransporter type 1 (NKCC1). The translation of this response to peripheral nerve terminals in people is so far unclear. We show here that GABA (EC50 = 16.
View Article and Find Full Text PDFGypenoside XVII Reduces Synaptic Glutamate Release and Protects against Excitotoxic Injury in Rats.
Biomolecules
May 2024
School of Medicine, Fu Jen Catholic University, New Taipei 24205, Taiwan.
Excitotoxicity is a common pathological process in neurological diseases caused by excess glutamate. The purpose of this study was to evaluate the effect of gypenoside XVII (GP-17), a gypenoside monomer, on the glutamatergic system. In vitro, in rat cortical nerve terminals (synaptosomes), GP-17 dose-dependently decreased glutamate release with an IC value of 16 μM.
View Article and Find Full Text PDFEvolutionary analysis reveals the origin of sodium coupling in glutamate transporters.
bioRxiv
April 2024
Dept. of Physiology & Biophysics, Weill Cornell Medical College, 1300 York Ave, New York, NY 10021, USA.
Secondary active membrane transporters harness the energy of ion gradients to concentrate their substrates. Homologous transporters evolved to couple transport to different ions in response to changing environments and needs. The bases of such diversification, and thus principles of ion coupling, are unexplored.
View Article and Find Full Text PDFValproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.
Life Sci
November 2022
Department of Medicine, University of California, Irvine, CA 92697, United States of America. Electronic address:
Neuronal uptake of ascorbic acid (AA) in humans occurs via the human sodium-dependent vitamin C transporter-2 (hSVCT2). Recent studies show that a significantly lower level of vitamin C is present in the blood of epileptic patients. Consequently, focused studies investigating the involved molecular mechanisms for hSVCT2 regulation are vital to enhance vitamin C body homeostasis.
View Article and Find Full Text PDFMonocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis.
J Biomed Sci
January 2022
College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University, Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Republic of Korea.
Background: Amyotrophic lateral sclerosis (ALS) is a devasting neurodegenerative disorder for which no successful therapeutics are available. Valproic acid (VPA), a monocarboxylate derivative, is a known antiepileptic drug and a histone deacetylase inhibitor.
Methods: To investigate whether monocarboxylate transporter 1 (MCT1) and sodium-coupled MCT1 (SMCT1) are altered in ALS cell and mouse models, a cellular uptake study, quantitative real time polymerase chain reaction and western blot parameters were used.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!