AI Article Synopsis
- The study investigated the anti-inflammatory effects of theophylline using a rat model of carrageenan-induced edema, showing that theophylline doses between 5-100 mg/kg reduced swelling in a dose-dependent manner.
- Theophylline's metabolites did not show significant anti-inflammatory effects when tested at an equivalent dose of 50 mg/kg.
- The results indicated that theophylline's anti-inflammatory action may involve the glucocorticoid-glucocorticoid receptor system since pretreatment with related inhibitors reversed its effects.
Article Abstract
Although theophylline has been suggested to have an anti-inflammatory effect, there have been few reports to show the in vivo effect and the mechanism of anti-inflammatory activity of theophylline experimentally. To reveal the anti-inflammatory activity of theophylline, we studied the effect of theophylline and its metabolites on carrageenan-induced edema in rat foot pad. Subcutaneous injection of theophylline (5 - 100 mg/kg) inhibited carrageenan-induced edema dose-dependently. Theophylline metabolites, that is, 1-methylxanthine, 3-methylxanthine, 1-methyluric acid, and 1,3-dimethyluric acid (equimolar dose to 50 mg/kg of theophylline), did not inhibit the edema significantly. The inhibitory effect of theophylline on carrageenan-induced edema disappeared by pretreatment with aminoglutethimide, an inhibitor of glucocorticoid synthesis and with mifepristone, an antagonist of the glucocorticoid receptor. These results suggest that theophylline itself has anti-inflammatory activity and the glucocorticoid-glucocorticoid receptor system is involved in the anti-inflammatory activity of theophylline.
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| http://dx.doi.org/10.1254/jphs.fp0071816 | DOI Listing |
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