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Vitamin B6 Alleviates Aflatoxin B1-Induced Impairment of Testis Development by Activating the PI3K/Akt Signaling Pathway.
J Agric Food Chem
January 2025
College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266100, China.
Aflatoxin B1 (AFB1) is a harmful environmental contaminant known to disrupt gut microbiota and cause health problems. In recent years, the role of vitamin B6 (VB6) in maintaining intestinal and reproductive health has attracted much attention. AFB1 has been found to damage the intestinal barrier and cause inflammation by disrupting the intestinal microbiota, particularly by increasing the abundance of .
View Article and Find Full Text PDFAssessing Aflatoxin Exposure in the United Arab Emirates (UAE): Biomonitoring AFM1 levels in Urine Samples and their Association with Dietary Habits.
Environ Toxicol Pharmacol
January 2025
Environmental Health Sciences, College of Health Sciences, University of Sharjah, United Arab Emirates (UAE); Sharjah Institute for Medical Research, University of Sharjah, UAE; Research Institute of Sciences and Engineering, University of Sharjah, UAE; Research Unit of Biomedicine and Internal Medicine, University of Oulu, Finland. Electronic address:
Background: Aflatoxins, known for their carcinoginc properties and produced by Aspergillus fungi, pose a substantial threat to public health, particularly in regions with hot and humid climates, where individuals are exposed to these toxins through contaminated food. The primary objective of this study was to assess the extent of aflatoxin exposure in the Emirate of Sharjah employing Aflatoxin M1 (AFM1) as a biomarker in urine samples from adult participants. Furthermore, this study aimed to explore the relationship between dietary habits and AFM1 levels in order to establish a potential link.
View Article and Find Full Text PDFMicrobial Contamination and Food Safety Aspects of Cassava Roasted Flour ("Rale") in Mozambique.
Microorganisms
January 2025
Department of Molecular Sciences, Uppsala BioCentrum, Swedish University of Agricultural Sciences, P.O. Box 7051, 750 07 Uppsala, Sweden.
Cassava is an important staple food that contributes to the food security of small-scale Mozambican farmers. In southern Mozambique, cassava roots are usually processed into cassava roasted flour, locally known as "rale". The handling and processing practices connected to "rale" production may introduce microbial contamination.
View Article and Find Full Text PDFSelenomethionine Attenuates Aflatoxin B-induced Liver Injury by Modulating the Gut Microbiota and Metabolites in Rabbits.
J Agric Food Chem
January 2025
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Dietary contamination with aflatoxin B (AFB), which can lead to severe liver damage, poses a great threat to livestock and poultry breeding and has detrimental impacts on food safety. Selenomethionine (SeMet), with anti-inflammatory, antioxidative, and detoxifying effects, is regarded as a beneficial food additive. However, whether SeMet can reduce AFB-induced liver injury and intestinal microbial disorders in rabbits remains to be revealed.
View Article and Find Full Text PDFAflatoxin B1: Challenges and Strategies for the Intestinal Microbiota and Intestinal Health of Monogastric Animals.
Toxins (Basel)
January 2025
Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA.
The objective of this review is to investigate the impacts of aflatoxins, particularly aflatoxin B1 (AFB), on intestinal microbiota, intestinal health, and growth performance in monogastric animals, primarily chickens and pigs, as well as dietary interventions to mitigate these effects. Aflatoxin B1 contamination in feeds disrupts intestinal microbiota, induces immune responses and oxidative damage, increases antioxidant activity, and impairs jejunal cell viability, barrier function, and morphology in the small intestine. These changes compromise nutrient digestion and reduce growth performance in animals.
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