AI Article Synopsis
- Obesity leads to chronic inflammation through high levels of TNF-alpha, which affects vascular health during insulin spikes.
- In a study, patients with metabolic syndrome showed reduced blood vessel responses to certain medications, but these responses improved after treatment with infliximab, which neutralizes TNF-alpha.
- The findings suggest that targeting TNF-alpha can enhance vascular function by reducing oxidative stress, highlighting the role of inflammation in vascular issues linked to metabolic syndrome.
Article Abstract
Objective: Obesity is associated with chronic inflammation due to overproduction of proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha. We assessed the effects of TNF-alpha neutralization by infliximab on vascular reactivity during hyperinsulinemia in obesity-related metabolic syndrome.
Research Design And Methods: Vascular responses to intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed in patients with metabolic syndrome, before and after administration of infliximab.
Results: Patients had blunted vasodilator responses to ACh and SNP during hyperinsulinemia compared with control subjects; a potentiation of the responsiveness to both ACh and SNP, however, was observed in patients following infliximab. The antioxidant vitamin C improved the vasodilator response to ACh in patients with metabolic syndrome, but its effect was not further enhanced by concurrent administration of infliximab.
Conclusions: TNF-alpha neutralization ameliorates vascular reactivity in metabolic syndrome during hyperinsulinemia, likely in relation to decreased oxidative stress, thereby suggesting an involvement of inflammatory cytokines in vascular dysfunction of these patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453644 | PMC |
| http://dx.doi.org/10.2337/dc08-0219 | DOI Listing |
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