AI Article Synopsis
- The study aimed to compare the effectiveness and safety of fixed-dose combinations (FDCs) with single-drug treatments in patients with pulmonary tuberculosis.
- A total of 293 patients were involved, with the FDC groups (A and B) demonstrating better sputum conversion rates and fewer side effects compared to the single-drug group (C).
- Group A had the highest conversion rate (98.9%) while Group B took the least time (32 days) to achieve conversion, highlighting the overall safety and efficacy of FDCs in treating TB.
Article Abstract
To evaluate the clinical and therapeutic value of 4 and 3 drug fixed dose combinations verses single drug formulations to treat pulmonary tuberculosis patients. The occurrence of adverse effects was also monitored. A total of 293 patients having sputum positive pulmonary tuberculosis were enrolled (Male: 187 and Female: 106). Patients with renal, hepatic, diabetic, cardiac problem and pregnancy were excluded from study. Patients were randomly selected into three groups (A, B, C). Group A and B were given FDCs and group C was given single drug formulations. All patients received 4 drugs in the intensive phase and 3 drugs in the continuation phase. Group A showed the highest percentage of patients who achieved sputum conversion (98.9%). The numbers of days taken to achieve sputum conversion on average were the least for Group B (32 days). When comparing the adverse effects, the patients of Group C suffered the most, with 22 patients who vomited repeatedly, 3 complaining of itching, 2 with Jaundice and 1 dead. There was no significant difference in the efficacy among the three treatment regimens. However the side effects observed in all three groups strongly indicate that FDCs are safer for treating TB patients. There were no side effects in the continuation phase.
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