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Understanding the unique patient-causal singularism and patient reported outcomes.
Qual Life Res
January 2025
IQVIA Patient Centered Solutions, Reading, UK.
Patient reported outcome measures (PROMs) now play a significant role in randomized control trials (RCTs) providing the basis for efficacy or safety endpoints. Most PROM data is quantitative and is summarized at the group level. Whilst PROM data is informative in providing the aggregated patient perspective on disease and interventions, it provides little information about the patients' individual experiences.
View Article and Find Full Text PDFEffect of anterior chamber depth on corneal endothelium following phacoemulsification among patients with different axial lengths.
Int Ophthalmol
January 2025
Ophthalmology Department, Faculty of Medicine - Suez Canal University Hospitals, 4.5 Kilo - Ring Road, Ismailia, 41522, Egypt.
Purpose: To assess the effect of anterior chamber depth on corneal endothelium using specular microscopy following uneventful phacoemulsification among cataract patients with different axial lengths.
Methods: The study was conducted in a quasi-experimental design including 300 eyes of 300 patients with grade three age-related nuclear cataract distributed equally based on their axial length into three equal groups. All eyes had grade three nuclear cataract.
Ecofriendly remediation of cadmium, lead, and zinc using dead cells of Microcystis aeruginosa.
Sci Rep
January 2025
Hydrobiology Lab, National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt.
The utilization of cyanobacteria toxin-producing blooms for metal ions adsorption has garnered significant attention over the last decade. This study investigates the efficacy of dead cells from Microcystis aeruginosa blooms, collected from agricultural drainage water reservoir, in removing of cadmium, lead, and zinc ions from aqueous solutions, and simultaneously addressing the mitigation of toxin-producing M. aeruginosa bloom.
View Article and Find Full Text PDFAn Underlying Mechanism for the Altered Hypoglycemic Effects of Nateglinide in Rats with Acute Peripheral Inflammation.
Biol Pharm Bull
January 2025
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan.
The hypoglycemic effects of nateglinide (NTG) were examined in rats with acute peripheral inflammation (API) induced by carrageenan treatment, and the mechanisms accounting for altered hypoglycemic effects were investigated. NTG was administered through the femoral vein in control and API rats, and its plasma concentration profile was characterized. The time courses of the changes in plasma glucose and insulin levels were also examined.
View Article and Find Full Text PDFPerylene diimide based fluorescent sensors for aqueous detection of perfluorooctane sulfonate (PFOS).
Anal Chim Acta
March 2025
Department of Materials Science and Engineering, University of Utah, Salt Lake City, UT, 84112, USA. Electronic address:
Background: Perfluorooctane sulfonate (PFOS), one of the most harmful members of the large group of per- and poly-fluoroalkyl substances (PFAS), is notorious for its environmental persistence, bioaccumulation, and toxic effects, raising serious environmental and health concerns. Developing rapid and sensitive methods to detect PFOS in water is critical for effective monitoring and protection against this hazardous chemical.
Results: In this study, we developed rapid and highly sensitive fluorometric sensors (PDI-2+ , PDI-6+ ) for detecting PFOS.
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