AI Article Synopsis
- Single-column chromatography is dominant in biopharmaceuticals, but multi-column methods like simulated moving bed (SMB) are gaining attention.
- A systematic economic appraisal is used to evaluate which chromatography method provides the best profit based on different project lifetimes.
- The study indicates that single-column processes are more cost-effective for short-term projects, while multi-column methods become more advantageous for projects lasting over 5 years, with SMB slightly outperforming Varicol in the long run.
Article Abstract
Single-column chromatography is widely used in the biopharmaceutical industries, although multi-column alternatives in the form of simulated moving bed (SMB) processes are now emerging. It may be difficult, however, to determine which column alternative will be best suited for a given application, and this work sets out to address this issue. A systematic approach is presented that is based on a full economic appraisal of each process alternative based on an optimization of the net annual profit. Single-column processes with and without recycling are considered, as are both the SMB and the Varicol process. The cyclic steady state for the SMB and Varicol processes is determined directly by complete discretization. The approach is applied to a case study based on a linear isotherm where it is found that for this particular system, a recycling policy is not necessary for the single column. When comparing the single-column process with the multi-column alternatives, the single column is the most economical provided the life time of the project is short; however, the economic benefits of the more capital-intensive multi-column processes are greater if the life time of the project is over 5 years. The SMB process is found to perform marginally better than the Varicol process over 15 years; however, this may be because not all extra degrees of freedom for the Varicol process were considered.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/bp070270m | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of the optimal performance of ModiCon and ModiCon+VariCol simulated moving bed variants.
J Chromatogr A
July 2022
Chemical Engineering Program/COPPE, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco G, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil.
The interest in the simulated moving bed (SMB) technology lies in its variants. Some of them that have a high potential to increase the performance in enantioseparations are the ModiCon and the ModiCon+VariCol. These variants are based on the modulation of feed concentration and a combination of feed concentration and length of zones modulations.
View Article and Find Full Text PDFOptimal performance comparison of the simulated moving bed process variants based on the modulation of the length of zones and the feed concentration.
J Chromatogr A
August 2021
Chemical Engineering Program/COPPE, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco G, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil.
The VariCol and ModiCon processes are two variants of the simulated moving bed (SMB) process, characterized by the modulation of the length of zones of the chromatographic column train and the feed concentration. These features give more flexibility than the conventional operation, leading to essential improvements in the separation and purification of mixtures. The optimal performance comparison of these two variants, the hybrid formed by their combination, and the conventional SMB process are scarce in the literature.
View Article and Find Full Text PDFOne-step optimization strategy in the simulated moving bed process with asynchronous movement of ports: A VariCol case study.
J Chromatogr A
December 2020
Programa de Engenharia Química PEQ/COPPE, Universidade Federal do Rio de Janeiro, Centro de Tecnologia, Bloco G, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, Brazil.
The VariCol process is a variant of the conventional simulated moving bed (SMB) process, distinguished by the asynchronous shifting of the inlet and outlet ports of the chromatographic column train. This feature allows for a more flexible operation in column utilization and can also achieve higher separation performances. However, to take full benefit out of it, the operating parameters, such as the strategy for port switching, must be optimal.
View Article and Find Full Text PDFEnantioseparation of racemic aminoglutethimide using asynchronous simulated moving bed chromatography.
J Chromatogr A
October 2016
Laboratory of Separation and Reaction Engineering (LSRE), Associate Laboratory LSRE/LCM, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.
The separation of aminoglutethimide enantiomers by the continuous multicolumn chromatographic processes were investigated experimentally and theoretically, where the columns were packed with cellulose tris 3,5-dimethylphenyl-carbamate stationary phase (brand name Chiralcel OD) and mobile phase was a mixture of n-hexane and ethanol with monoethanolamine additive. The continuous enantioseparation processes included a synchronous shifting process (SMB) and an asynchronous shifting process (VARICOL), which allowed reducing the column number (here from six-column SMB to five-column VARICOL process). Transport-dispersive model with the consideration of both intraparticle mass transfer resistance and axial dispersion was adopted to design and optimize the operation conditions for the separation of aminoglutethimide enantiomers by SMB process and VARICOL process.
View Article and Find Full Text PDFExperiment and modeling for the separation of guaifenesin enantiomers using simulated moving bed and Varicol units.
J Chromatogr A
October 2014
Laboratory of Separation and Reaction Engineering (LSRE), Associate Laboratory LSRE/LCM, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.
The separation of guaifenesin enantiomers by both simulated moving bed (SMB) process and Varicol process was investigated experimentally and theoretically, where the columns were packed with cellulose tris 3,5-dimethylphenylcarbamate (Chiralcel OD) stationary phase and a mixture of n-hexane and ethanol was used as mobile phase. The operation conditions were designed based on the separation region with the consideration of mass transfer resistance and axial dispersion, and the experiments to separate guaifenesin enantiomers were carried out on VARICOL-Micro unit using SMB process with the column configuration of 1/2/2/1 and Varicol process with the column configuration of 1/1.5/1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!