Objective: The purpose of this study was to explore whether a longitudinal comparison between reported and predicted health could be used as a method of identifying subjects who potentially experienced response shift.
Methods: A response-shift model was developed using data from a longitudinal study of stroke in which measures of stroke impact were made at study entry and at 1, 3, 6, and 12 months post stroke. Residuals from a random effects model were centered and used to create trajectories. This model was tested against a data set from a study in which the then-test had been administered. Twenty simulated data sets were also generated to examine how much of response shift could be attributed to random error.
Results: Group-based trajectory analysis identified seven trajectory groups. The majority (67%) of the 387 persons showed no response shift over time, whereas 15% lowered and 13% raised their health over time, disproportionally to that predicted.
Conclusion: Results of the validation studies were supportive that this methodology identifies response shift, but further research is required to compare results with other methodologies and other predictive models.
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http://dx.doi.org/10.1007/s11136-008-9329-2 | DOI Listing |
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January 2025
Jiangxi Provincial Key Laboratory of Organic Functional Molecules; Institute of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, PR China.
Glutathione (GSH) plays an important role in maintaining redox homeostasis in biological systems. Development of reliable glutathione sensors is of great significance to better understand the role of biomolecules in living cells and organisms. Based on the advantages of the photophysical properties of iridium complexes, we proposed a "turn-on" phosphorescent sensor.
View Article and Find Full Text PDFNanomedicine (Lond)
January 2025
Department of Orthopedic, Spinal Pain Research Institute, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Background: Gene therapy is garnering increasing support due to its potential for a "once-delivered, lifelong benefit." The limitations of traditional gene delivery methods have spurred the advancement of bionanomaterials. Despite this progress, a thorough analysis of the evolution, current state, key contributors, focal studies, and future directions of nanomaterials in gene delivery remains absent.
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January 2025
SEAMARCO, Julianalaan 46, 3843 CC Harderwijk, the Netherlands.
In their Comment, Tougaard et al. [(2025). J.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun 130102, China.
Although microplastics (MPs) toxicity to soil microorganisms has been preliminarily explored, the underlying reasons affecting the direction of microbial community succession are unclear. This study aimed to investigate the impacts of MPs infer community assembly mechanisms through phylogenetic bin-based null model analysis, network models, and protein function prediction in five typical Northeast China five typical soils. The results show that microbial communities in soils with high organic matter exhibit a stronger response to MPs, with enhanced protein functionality, network regulation, and assembly processes.
View Article and Find Full Text PDFElife
January 2025
Centre for Cellular Biology and Signalling, Zhejiang University-University of Edinburgh (ZJU-UoE) Institute, Haining, China.
Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including those originating from mitochondria. By utilizing mass spectrometry-based cellular thermal shift assay (MS-CETSA), we uncovered that phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitory protein (RKIP), is thermally stabilized by stresses which induce mitochondrial ISR.
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