AI Article Synopsis
- Eosinophils are versatile immune cells that play important roles in both starting and sustaining various inflammatory responses and adjusting immune system functions.
- The review discusses key aspects of eosinophil biology, including how they develop, the characteristics and functions of their granule and surface proteins, and the processes involved in their degranulation.
- It also explores new insights into eosinophils' roles in maintaining body balance and their interactions with other immune cells, as well as their implications in diseases like asthma and gastrointestinal issues, along with potential treatment strategies for related conditions.
Article Abstract
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. In this review, the biology of eosinophils is summarized, focusing on transcriptional regulation of eosinophil differentiation, characterization of the growing properties of eosinophil granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of eosinophil degranulation. New views on the role of eosinophils in homeostatic function are examined, including developmental biology and innate and adaptive immunity (as well as their interaction with mast cells and T cells) and their proposed role in disease processes including infections, asthma, and gastrointestinal disorders. Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized.
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| http://dx.doi.org/10.1111/j.1365-2222.2008.02958.x | DOI Listing |
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