Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres containing flurbiprofen were prepared by an oil-in-water emulsion solvent evaporation method, in order to develop a particulate drug delivery system for localized administration. A response surface method (RSM) using a central composite design was employed to evaluate the effect of the poly(vinyl alcohol) (PVA) (%, w/v) concentration in the aqueous phase and the PHBV concentration in the organic phase (%, w/v) on some of the resulting microspheres properties. The response variables were the encapsulation efficiency (EE), the mean particle size, the width of particle size distribution (expressed by the SPAN value) and the required time for the in vitro release of 50% of the encapsulated drug (t(50%)). Second-order polynomial and linear equations were fitted to experimental data and were also used to interpret the results. Results indicated that the concentration of the stabilizer (PVA) showed a highly negative effect on the EE probably due to the increased drug solubility in the aqueous phase as a result of the higher PVA concentrations. Particle diameter mean size increased with the increased polymer concentration while the width of the particle size distribution was found to decrease with the increase of the stabilizer agent. Finally, results indicated that none of the investigated variables presented a significant effect on the t(50%) values.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/02652040701814140 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preparation and characterization of PEG-Dex macromolecular schiff base particles and their application on the stabilization of water-in-water emulsion.
Sci Rep
December 2024
Gansu Provincial Ecological Environment Engineering Assessment Center, Lanzhou, 730000, People's Republic of China.
In this study, polyethylene glycol (PEG) and dextran (Dex) were chemically modified to obtain amino-functionalized PEG (PEG-(NH)) and oxidized dextran (ODex). They were subsequently reacted via -NH and -CHO groups to synthesize a macromolecular Schiff base particle. The structures, morphologies, and thermal properties of the macromolecular Schiff base particle were characterized using Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and thermogravimetry analysis (TGA).
View Article and Find Full Text PDFImpact of magnetorheological fluid composition on their behaviour in gradient pinch mode.
Sci Rep
December 2024
Faculty of Mechanical Engineering, Brno University of Technology, Technická 2, Brno, Czechia, Czechia.
Magnetorheological (MR) fluids can be utilized in one of the fundamental operating modes of which the gradient pinch mode has been the least explored. In this unique mode non-uniform magnetic field distributions are taken advantage of to develop a so-called Venturi-like contraction in MR fluids. By adequately directing magnetic flux the material can be made solidified in the regions near the flow channel wall, thus creating a passage in the middle of the channel for the fluid to pass through.
View Article and Find Full Text PDFNucleation and growth of zinc-templated mesoporous selenium nanoparticles and potential non-thermal effects during their microwave-assisted synthesis.
Sci Rep
December 2024
Institute of Radioelectronics and Multimedia Technology, Warsaw University of Technology, Warsaw, Poland.
The effects of 5.8-GHz microwave (MW) irradiation on the synthesis of mesoporous selenium nanoparticles (mSeNPs) in aqueous medium by reduction of selenite ions with ascorbic acid, using zinc nanoparticles as a hard template and cetyltrimethylammonium bromide (CTAB) as a micellar template, are examined for the first time with a particular emphasis on MW-particle interactions and the NPs morphology. This MW-assisted synthesis is compared to 2.
View Article and Find Full Text PDFIn situ hydrothermal synthesis of visible light active sulfur doped TiO from industrial TiOSO solution.
Sci Rep
December 2024
College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu, 610500, China.
A cost-effective industrial TiOSO solution was employed to fabricate visible light active sulfur-doped titanium dioxide (S-TiO) via a facile hydrothermal method. The effect of calcination temperature on morphology, particle size, crystallinity, and photocatalytic property of S-TiO was systematically investigated. Successful incorporation of sulfur into TiO was confirmed by carbon-sulfur analysis, X-ray photoelectron spectroscopy (XPS), and Energy dispersive spectrometer (EDS).
View Article and Find Full Text PDFVegetation restoration can be effective in containing gully head advance. However, the effect of vegetation restoration type on soil aggregate stability and erosion resistance at the head of the gully is unclear. In this study, five types of vegetation restoration-Pinus tabulaeformis (PT), Prunus sibirica (PS), Caragana korshinskii (CKS), Hippophae rhamnoides (HR), and natural grassland (NG, the dominant species is Leymus chinensis)-in the gully head were studied.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!