Endoglin (CD105) is an accessory protein of the transforming growth factor-beta receptor system expressed on vascular endothelial cells. Mutation of the endoglin gene is associated with hereditary hemorrhagic telangiectasias, or Osler-Weber-Rendu syndrome, and has been studied extensively in the context of this disease. The expression of endoglin is elevated on the endothelial cells of healing wounds, developing embryos, inflammatory tissues, and solid tumors. Endoglin is a marker of activated endothelium, and its vascular expression is limited to proliferating cells. Recent studies identified endoglin expression in several solid tumor types, with the level of expression correlating with various clinicopathologic factors including decreased survival and presence of metastases. Attempts to target endoglin and the cells that express this protein in tumor-bearing mice have yielded promising results.
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Department of Biochemistry, University of Lucknow, Lucknow, India.
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Chinese Academy of Inspection and Quarantine, Beijing 100176, China. Electronic address:
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Department of Biochemistry, School of Life Sciences, University of Sussex, Brighton, UK.
Article Synopsis
- The study focuses on the importance of the microvessel compartment in the tumor environment of endometrioid adenocarcinoma (EA) and explores the implications of vasculogenic mimicry (VM), CD146, and CD105 microvessel density on clinical prognosis.
- A total of 188 EA cases were examined using specific staining techniques, revealing that higher levels of VM channels and CD146/CD105 microvessels were linked to worse prognoses.
- The findings suggest that these factors could serve as independent indicators of prognosis and potential targets for antiangiogenic therapy, although further research is needed for confirmation.
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