AI Article Synopsis
- - Carbohydrates serve as effective carriers for peptide antigens in vaccines, enhancing their recognition by the immune system and protecting them from degradation.
- - Researchers developed a promising carbohydrate-based vaccine that combines specific peptide antigens from group A streptococcal (GAS) M proteins with carbohydrate cores linked to lipophilic amino acids.
- - In vivo studies showed that this self-adjuvanting liposaccharide vaccine elicited strong immune responses, demonstrated by high serum IgG antibody levels against the peptide epitopes J8 and J14.
Article Abstract
Carbohydrates, as carriers, providing numerous attachment points for the conjugation of peptide antigens and their optimal orientation for the recognition by cells of the immune system, reducing degradation of the attached peptide antigens and many other advantages make carbohydrate-based vaccine highly promising approach. Multiple copies of a single group A streptococcal (GAS) M protein derived specific peptide antigens (J8 or J14) were coupled onto carbohydrate cores (D-glucose and D-galactose) linked to lipophilic amino acids to produce a self-adjuvanting liposaccharide vaccine against GAS strains. In vivo experiments showed high serum IgG antibody titers against each of the incorporated peptide epitopes, J8 or J14.
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| http://dx.doi.org/10.1002/bip.20992 | DOI Listing |
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