The anaphase-promoting complex (APC) mediates the ubiquitination and degradation of key M-phase regulators, including cyclins and the anaphase inhibitor securin. Intriguingly, securin can also inhibit the degradation of cyclin B. This competition between substrates permits the accumulation of enough cyclin to drive entry into M phase.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ncb0408-381 | DOI Listing |
Publication Analysis
Top Keywords
securin' m-phase
4
m-phase entry
4
entry anaphase-promoting
4
anaphase-promoting complex
4
complex apc
4
apc mediates
4
mediates ubiquitination
4
ubiquitination degradation
4
degradation key
4
key m-phase
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!