Transforming growth factor (TGF)-beta is a potent growth inhibitor of various types of cells, whereas it stimulates deposition of extracellular matrix proteins and induction of epithelial-to-mesenchymal transition (EMT). TGF-beta thus plays two distinct and opposing roles in cancer progression. In the present study, we have developed a useful method that enables monitoring of tumor and its TGF-beta signaling within the same animal using in vivo bioluminescent imaging.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
[tgf-beta signaling
4
signaling bone
4
bone metastasis
4
metastasis breast
4
breast cancer
4
cancer in-vivo
4
in-vivo imaging]
4
imaging] transforming
4
transforming growth
4
growth factor
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!