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Design and development of Vaginal wall mimicking Poly (ε-caprolactone) based nanofibrous prosthetic mesh for pelvic organ prolapse: Evaluation of biocompatibility and antibacterial ability.
Biomed Mater
December 2024
Department of Chemical Engineering, Indian Institute of Technology - Bombay, Powai, Mumbai 400 076, Mumbai, Maharastra, 400076, INDIA.
Mechanical non-conformance of conventionally used transvaginal non-degradable meshes has led to complications like organ perforation, dyspareunia caused by mesh stiffness, and stress shielding. In this study, we have solved the dire need of mimicking the mechanical properties of vaginal wall by designing and developing a soft and elastic mesh made of polycaprolactone (PCL), citric acid modified polyethylene glycol (PEGC) and zinc oxide (ZnO) prepared through electrospinning and is tested in-vitro and in-vivo. Mesh containing 90:10:0.
View Article and Find Full Text PDFVery long-term outcomes of robotic mesh sacrocolpopexy for pelvic organ prolapse repair.
J Robot Surg
December 2024
Department of Urology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9110, USA.
To assess the very long-term functional outcomes and complications of robot-assisted sacrocolpopexy (RASC) at our institution where this robotic technology for pelvic organ prolapse (POP) repair has been available since 2006. A retrospective review of a cohort of women who underwent a RASC was performed by an investigator not involved in the clinical care of these patients. Women with no electronic medical record follow-up in the last 2 years were contacted by telephone.
View Article and Find Full Text PDFObjective: Over the last two decades one of the main surgical treatment for stress urinary incontinence (SUI) and pelvic organ prolapse (POP) surgery was the insertion of non-absorbable mesh to restore continence and prolapse respectively. Over time complications arose including mesh-associated pain syndrome (MAPS), mesh exposure, mesh, erosion, chronic bladder/vaginal infections, and dyspareunia. Consequently, women chose surgical mesh removal to counter these problems.
View Article and Find Full Text PDFLong-Term Outcomes of Tension-Free Vaginal Tape Obturator: Efficacy and Safety at Long-Term Follow-Up.
J Clin Med
September 2024
Department of Obstetrics and Gynecology, Del Ponte Hospital, University of Insubria, 21100 Varese, Italy.
The use of tension-free vaginal tape obturator (TVT-O) for the treatment of stress urinary incontinence (SUI) has been widely debated over the last decade due to the lack of evidence on its long-term outcomes. The aim of this prospective study is to assess, for the first time in the available literature, the efficacy and safety of TVT-O implantation in women with pure SUI over a 17-year follow-up period. : We included all women who complained of pure SUI symptoms (confirmed urodynamically) and underwent the TVT-O procedure.
View Article and Find Full Text PDFModification of transvaginal polypropylene mesh with co-axis electrospun nanofibrous membrane to alleviate complications following surgical implantation.
J Nanobiotechnology
October 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, No. 1 Shuaifuyuan, Dongcheng District, Beijing, China.
Article Synopsis
- Surgeries using synthetic mesh for pelvic organ prolapse can cause complications like mesh erosion and pain, prompting research to improve outcomes with a modified mesh featuring a nanofibrous membrane made of polyurethane and gelatin.* -
- In laboratory studies, the modified mesh showed better cell growth and tissue interactions and was tested in a rat model, where it did not expose the mesh or penetrate surrounding tissues, demonstrating improved biocompatibility compared to standard polypropylene mesh.* -
- Results indicated that the modified mesh increased collagen content and tissue elasticity while reducing collagen breakdown, suggesting it promotes healthier tissue repair and has potential benefits for patients undergoing such surgeries.*
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