Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2415750 | PMC |
| http://dx.doi.org/10.1128/AAC.01594-07 | DOI Listing |
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