In this study we present new data showing strain-specific differences on the effect of commercially available probiotic drinks in an EAE rat autoimmune model for multiple sclerosis. In this particular model, we conclude that these drinks do not enhance but rather suppress the disease. We suggest that conclusions on probiotics are limited to specific strains and models and not generalised. We further suggest that physiological use (normal route, normal dose, normal growth phase, specific strain or substrain/species) is studied in all cases, so as not to overwhelm (high dose) or circumvent natural immune processing.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.vaccine.2008.02.035 | DOI Listing |
World J Microbiol Biotechnol
December 2024
Departamento de Biología Molecular, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), Ruta Nacional 36 Km 601, 5800, Río Cuarto, Córdoba, CP, Argentina.
Arsenic (As) contamination in agricultural groundwater and soil is a significant economic and health problem worldwide. It inhibits soybean (Glycine max (L.) Merr.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzębiec, Poland.
Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by alterations in social communication and repetitive behaviors. Advanced maternal age is associated with an increased risk of bearing children affected by autism but the etiological factors underlying this association are not well known. Here, we investigated the effects of advanced maternal age on offspring health and behavior in two genetically divergent mouse strains: the BTBR T Itpr3/J (BTBR) mouse model of idiopathic autism, and the C57BL/6 J (B6) control strain, as a model of genetic variability.
View Article and Find Full Text PDFComput Biol Med
December 2024
Department of Mathematics, Capital University of Science and Technology, Islamabad, 44000, Pakistan.
The dynamic behavior of articular cartilage (a soft porous biological tissue) with strain-dependent nonlinear permeability under cyclic compressive loading and magnetic field is investigated computationally. The compressive force is applied on top surface of the cylindrical plug of the tissue by means of a porous filter. The study of mechanical and deformational behavior of soft porous tissues such as articular cartilage under dynamic compressive loading and magnetic field is useful in understanding the underlying mechano-biological process that may lead to the development of a treatment and recovery protocol in a diseased state.
View Article and Find Full Text PDFNanoscale Horiz
December 2024
2D Foundry Research Group, Instituto de Ciencia de Materiales de Madrid (ICMM-CSIC), 28049 Madrid, Spain.
We investigated the effect of uniaxial strain on the electrical properties of few-layer ZrSe devices under compressive and tensile strains applied up to ±0.62% along different crystal directions. We observed that the piezoresponse, the change in resistance upon application of strain, of ZrSe strongly depends on both the direction in which electrical transport occurs and the direction in which uniaxial strain is applied.
View Article and Find Full Text PDFMicrob Pathog
December 2024
Centro de Investigación y Desarrollo en Ciencia y Tecnología de los Alimentos (CCT- La Plata CONICET, CIC-PBA, Facultad de Ciencias Exactas, UNLP), Argentina; Cátedra de Microbiología. Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, UNLP), Argentina; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina. Electronic address:
Clostridioides difficile is a spore-forming pathogen capable of causing severe disease in humans. Critical stages in the biological cycle of this microorganism include sporogenesis/germination and toxin production by vegetative cells. Antagonizing these pivotal events could aid in prevention and treatment to manage this pathogen.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!