AI Article Synopsis
- The study involved 84 breast cancer patients who were given a daily supplement (100 mg co-enzyme Q10, 10 mg riboflavin, 50 mg niacin) along with tamoxifen.
- Patients receiving this combination showed significant increases in DNA repair enzymes and improved DNA methylation patterns compared to those only on tamoxifen or not treated at all.
- These findings indicate a potential reduction in tumor burden and suggest a better prognosis and effectiveness of the combined treatment.
Article Abstract
In the present study, eighty-four breast cancer patients were randomized to receive a daily supplement of 100 mg co-enzyme Q10, 10 mg riboflavin and 50 mg niacin (CoRN), one dosage per d along with 10 mg tamoxifen twice per d. A significant increase in poly(ADP-ribose) polymerase levels and disappearance of RASSF1A DNA methylation patterns were found in patients treated with supplement therapy along with tamoxifen compared to untreated breast cancer patients and tamoxifen alone-treated patients. An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumour burden and may suggest good prognosis and efficacy of the treatment.
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| http://dx.doi.org/10.1017/S0007114508968276 | DOI Listing |
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