First report of a funnel-web spider envenoming syndrome in Brisbane.

Emerg Med Australas

Royal Brisbane and Women's Hospital, Greenslopes Private Hospital, Herston, Queensland, Australia.

Published: April 2008

AI Article Synopsis

  • The Australian funnel-web spider is considered one of the most venomous spiders globally and typically resides in moist, cool environments like rainforests along the eastern coast of Australia.
  • Previous studies indicated these spiders were found only near bushland or native rainforests in the outskirts of Brisbane.
  • A recent report documents the first case of funnel-web spider envenoming in inner-city Brisbane, highlighting the need for emergency departments to be prepared and have antivenom available.

Article Abstract

The Australian funnel-web spider, arguably the most venomous spider in the world, is distributed along the Australian eastern seaboard, typically preferring moist, cool, sheltered habitats such as rainforests. Prior surveys around Brisbane have only ever demonstrated funnel-web spiders in the outskirts of the city contiguous with bushland or native rainforest. We report the first funnel-web spider envenoming syndrome presumed from a spider resident to inner-city Brisbane. Emergency departments in the greater Brisbane area should be prepared for this clinical scenario, and stocks of Commonwealth Serum Laboratory funnel-web spider antivenom, until now thought to be unnecessary, should be readily available.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1742-6723.2008.01069.xDOI Listing

Publication Analysis

Top Keywords

funnel-web spider
16
report funnel-web
8
spider envenoming
8
envenoming syndrome
8
spider
6
brisbane
4
syndrome brisbane
4
brisbane australian
4
funnel-web
4
australian funnel-web
4

Similar Publications

The Sydney funnel-web spider Atrax robustus O. Pickard-Cambridge, 1877 is an iconic Australian species and considered among the most dangerously venomous spiders for humans. Originally described in 1877 from a single specimen collected in "New Holland", this spider has a complex taxonomic history.

View Article and Find Full Text PDF

Mechanism of acid-sensing ion channel modulation by Hi1a.

J Gen Physiol

December 2024

Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.

Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by extracellular acidification. Amongst many pathological roles, ASICs are an important mediator of ischemic cell death and hence an attractive drug target for stroke treatment as well as other conditions. A peptide called Hi1a, isolated from Australian funnel web spider venom, inhibits ASIC1a and attenuates cell death in a stroke model up to 8 h after stroke induction.

View Article and Find Full Text PDF

Transcriptomic analyses reveals a diverse venom composition in Agelena limbata (Araneae: Agelenaidae).

Comp Biochem Physiol Part D Genomics Proteomics

December 2024

Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Dali University, Dali 671000, China; National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali 671000, China. Electronic address:

Spider venom is a natural source of diverse biomolecules, but due to technical limitations, only a small fraction has been studied. With the advancement of omics technologies, research on spider venom has broadened, greatly promoting systematic studies of spider venom. Agelena limbata is a common spider found in vegetation, known for constructing funnel-shaped webs, and feeding on insects such as Diptera and Homoptera.

View Article and Find Full Text PDF

From genome to proteome: Comprehensive identification of venom toxins from the Chinese funnel-web spider (Macrothelidae: Macrothele yani).

Int J Biol Macromol

May 2024

Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R & D, Dali University, Dali 671000, China; National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali 671000, China; Innovative Team of Dali University for Medicinal Insects & Arachnids Resources Digital Development, Dali 671000, China. Electronic address:

Article Synopsis
  • * This study assembled the high-quality genome of Macrothele yani, totaling 6.79 Gb with over 39,000 annotated protein-coding genes, making it the spider genome with the highest gene count so far.
  • * The research identified 194 venom toxins through advanced techniques, enhancing our understanding of these compounds' potential in medicine and agriculture, while also providing a crucial genomic resource for future studies on spider biology.
View Article and Find Full Text PDF

Acid-sensing ion channel 1a (ASIC1a) is a proton-gated channel involved in synaptic transmission, pain signalling, and several ischemia-associated pathological conditions. The spider venom-derived peptides PcTx1 and Hi1a are two of the most potent ASIC1a inhibitors known and have been instrumental in furthering our understanding of the structure, function, and biological roles of ASICs. To date, homologous spider peptides with different pharmacological profiles at ASIC1a have yet to be discovered.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!