In situ commissioning of the Blower-gun injector for launching cryogenic deuterium pellets at ASDEX Upgrade tokamak was performed. This injector is designed for high repetitive launch of small pellets for edge localised modes pacing experiments. During the investigation the final injection geometry was simulated with pellets passing to the torus through a 5.5 m long guiding tube. For investigation of pellet quality at launch and after tube passage laser flash camera shadowgraphy diagnostic units before and after the tube were installed. As indicator of pellet quality we adopted the pellet mass represented by the volume of the main remaining pellet fragment. Since only two-dimensional (2D) shadow images were obtained, a reconstruction of the full three-dimensional pellet body had to be performed. For this the image was first converted into a 1-bit version prescribing an exact 2D contour. From this contour the expected value of the volume was calculated by Bayesian analysis taking into account the likely cylindrical shape of the pellet. Under appropriate injection conditions sound pellets with more than half of their nominal mass are detected after acceleration; the passage causes in average an additional loss of about 40% to the launched mass. Analyzing pellets arriving at tube exit allowed for deriving the injector's optimized operational conditions. For these more than 90% of the pellets were arriving with sound quality when operating in the frequency range 5-50 Hz.
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Sci Adv
December 2024
Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada.
The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins TTC7 and FAM126. Fundamental to PI4KA activity is its targeted recruitment to the plasma membrane by the lipidated proteins EFR3A and EFR3B.
View Article and Find Full Text PDFAnal Chem
December 2024
Department of Chemistry, Ulsan National Institute of Science and Technology, 44919 Ulsan, Republic of Korea.
Hydrogen isotope separation is a complex task due to the nearly identical physical and thermodynamic properties of isotopes, such as deuterium and protium. Traditional methods, including cryogenic distillation, exhibit limitations such as low selectivity and high energy consumption. Recent advancements utilizing the quantum sieving effect in crystalline porous materials have shown promise under cryogenic conditions, but experimental approaches using larger, more practical sample sizes remain scarce.
View Article and Find Full Text PDFEur Phys J D At Mol Opt Phys
October 2024
Laboratoire Kastler Brossel, Sorbonne Université, CNRS, ENS-PSL Université, Collège de France, 75252 Paris, France.
Nat Commun
October 2024
Integrated Drug Discovery, Sanofi R&D, Paris, France.
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are overexpressed in some tumor types. The antibody-drug conjugate tusamitamab ravtansine specifically recognizes the A3-B3 domains of human CEACAM5 (hCEACAM5). To understand this specificity, here we map the epitope-paratope interface between the A3-B3 domains of hCEACAM5 (hCEACAM5) and the antigen-binding fragment of tusamitamab (tusa Fab).
View Article and Find Full Text PDFRev Sci Instrum
October 2024
Laboratory for Laser Energetics, University of Rochester, Rochester, New York 14623-1299, USA.
A deep-learning convolutional neural network (CNN) is used to infer, from x-ray images along multiple lines of sight, the low-mode shape of the hot-spot emission of deuterium-tritium (DT) laser-direct-drive cryogenic implosions on OMEGA. The motivation of this approach is to develop a physics-informed 3-D reconstruction technique that can be performed within minutes to facilitate the use of the results to inform changes to the initial target and laser conditions for the subsequent implosion. The CNN is trained on a 3D radiation-hydrodynamic simulation database to relate 2D x-ray images to 3D emissivity at stagnation.
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