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Deciphering the Coupling State-Dependent Transcription Termination in the Escherichia coli Galactose Operon.
Mol Microbiol
January 2025
Department of Biological Sciences, College of Biological Sciences and Biotechnology, Chungnam National University, Daejeon, Republic of Korea.
The distance between the ribosome and the RNA polymerase active centers, known as the mRNA loop length, is crucial for transcription-translation coupling. Despite the existence of multiple expressomes with varying mRNA loop lengths, their in vivo roles remain largely unexplored. This study examines the mechanisms governing transcription termination in the Escherichia coli galactose operon, revealing a crucial role in the transcription and translation coupling state.
View Article and Find Full Text PDFA distinct hypothalamus-habenula circuit governs risk preference.
Nat Neurosci
January 2025
Brain Research Institute, University of Zurich, Zurich, Switzerland.
Appropriate risk evaluation is essential for survival in complex, uncertain environments. Confronted with choosing between certain (safe) and uncertain (risky) options, animals show strong preference for either option consistently across extended time periods. How such risk preference is encoded in the brain remains elusive.
View Article and Find Full Text PDFEffect of fructooligosaccharides in full-hydrated lactic acid bacteria membrane models during thermal stress: A molecular simulation study.
Food Res Int
January 2025
University of Coimbra, CERES, Department of Chemical Engineering, Rua Sílvio de Lima, Coimbra 3030-790, Portugal. Electronic address:
Fructooligosaccharides (FOS) are a promising choice for cryoprotection of lactic acid bacteria (LAB). However, the mechanism by which this protection takes place is not well understood. Molecular simulation is a key tool for gathering insights into complex physicochemical problems like this.
View Article and Find Full Text PDFRecent research progress on the biological functions, synthesis and applications of selenium nanoparticles.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Chongqing Key Laboratory of Reproductive Health and Digital Medicine, Department of Laboratory Medicine, Chongqing General Hospital, School of Medicine, Chongqing University, Chongqing 400044, China. Electronic address:
Selenium is an essential trace element that is involved in a variety of complex biological processes and has a significant positive effect on the prevention and treatment of cardiovascular disease, inflammatory diseases, and cancer. Selenium in the body is mainly provided by daily meals. However, selenium has two sides, beneficial in moderation and harmful in excess.
View Article and Find Full Text PDFNeural Architecture Search for biomedical image classification: A comparative study across data modalities.
Artif Intell Med
January 2025
Koç University, Department of Physics, Electrical and Electronics Engineering, Istanbul, Turkiye. Electronic address:
Deep neural networks have significantly advanced medical image classification across various modalities and tasks. However, manually designing these networks is often time-consuming and suboptimal. Neural Architecture Search (NAS) automates this process, potentially finding more efficient and effective models.
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