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Molecular, Histological, and Functional Changes in Acta1-MCM;FLExDUX4/+ Mice.
Int J Mol Sci
October 2024
NIHR Biomedical Research Centre, University College London, Great Ormond Street Institute of Child Health and Great Ormond Street Hospital NHS Trust, London WC1N 1EH, UK.
DUX4 is the major gene responsible for facioscapulohumeral dystrophy (FSHD). Several mouse models expressing DUX4 have been developed, the most commonly used by academic laboratories being ACTA1-MCM/FLExDUX4. In this study, molecular and histological modifications in the tibialis anterior and quadriceps muscles were investigated in this model at different time points.
View Article and Find Full Text PDFSynthesis and Antitumour Activity of Hybrid Compounds Based on 4-Aminophenylarsonic Acid and Spatially Hindered Phenols.
Dokl Biochem Biophys
October 2024
Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russia.
One of the main modern approaches to the creation of effective drugs is the design of new biologically active substances containing two or more pharmacophore groups in their structure. In recent years, there have been many publications on the synthesis and study of biological activity, including antitumour activity, of new organo-arsenic compounds. It is known that spatially hindered phenols can also have antitumor activity, so the synthesis and study of hybrid compounds based on organo-arsenic compounds and spatially hindered phenols is a relevant area of research.
View Article and Find Full Text PDFMechanisms of tamoxifen resistance: insight from long non-coding RNAs.
Front Oncol
October 2024
Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Breast cancer(BC) is the second most prevalent tumor in the world and one of the most lethal tumors in women. Patients with estrogen receptor-positive breast cancer can obtain significant advantages from endocrine therapies including tamoxifen, aromatase inhibitors, and others. However, the development of primary or acquired drug resistance ultimately leads to discontinuation of treatment with adverse consequences for breast cancer patients, and the underlying mechanisms have not been fully elucidated.
View Article and Find Full Text PDFA vector system encoding histone H3 mutants facilitates manipulations of the neuronal epigenome.
Sci Rep
October 2024
Department of Biology, Indiana University, Bloomington, IN, 47405, USA.
The differentiation of developmental cell lineages is associated with genome-wide modifications in histone H3 methylation. However, the causal role of histone H3 methylation in transcriptional regulation and cell differentiation has been difficult to test in mammals. The experimental overexpression of histone H3 mutants carrying lysine-to-methionine (K-to-M) substitutions has emerged as an alternative tool for inhibiting the endogenous levels of histone H3 methylation at specific lysine residues.
View Article and Find Full Text PDFGeneration of affinity maps for thiazolidinediones with human serum albumin using affinity microcolumns. II. Effects of advanced glycation end products on multisite drug binding.
J Chromatogr B Analyt Technol Biomed Life Sci
October 2024
Department of Chemistry, University of Nebraska-Lincoln, USA. Electronic address:
Article Synopsis
- The study investigated how two drugs, pioglitazone and rosiglitazone, interact with modified forms of human serum albumin (HSA) to explore multisite protein interactions.
- Strong binding was observed at Sudlow sites I and II, but modifications to HSA decreased the binding affinities of both drugs, particularly with glyoxal (Go) and methylglyoxal (MGo) modifications.
- The research highlights the use of affinity microcolumns to analyze complex drug-protein interactions, which may have implications for understanding how drug efficacy can change in diseases like diabetes.
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