The leaky integrate-and-fire model for neuronal spiking events driven by a periodic stimulus is studied by using the Fokker-Planck formulation. To this purpose, an essential use is made of the asymptotic behavior of the first-passage-time probability density function of a time homogeneous diffusion process through an asymptotically periodic threshold. Numerical comparisons with some recently published results derived by a different approach are performed. Use of a new asymptotic approximation is then made in order to design a numerical algorithm of predictor-corrector type to solve the integral equation in the unknown first-passage-time probability density function. Such algorithm, characterized by a reduced (linear) computation time, is seen to provide a high computation accuracy. Finally, it is shown that such an approach yields excellent approximations to the firing probability density function for a wide range of parameters, including the case of high stimulus frequencies.
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http://dx.doi.org/10.1016/j.mbs.2008.02.003 | DOI Listing |
BMJ Health Care Inform
January 2025
Biomedical Informatics and Clinical Epidemiology Department, Chiang Mai University Faculty of Medicine, Chiang Mai, Thailand.
Background: Low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) levels are paramount in atherosclerotic cardiovascular disease risk management. However, 94.4% of Thai young adult are unaware of their condition.
View Article and Find Full Text PDFLeg Med (Tokyo)
January 2025
Department of Forensic Sciences, Faculty of Medicine, University of Crete, Greece.
Examining the clavicle by macroscopic or radiologic techniques is a well-established method in forensic age estimation in living and dead individuals. The present study examined 196 CT (computed tomography scan) images of native patients from the archive of the medical imaging laboratory of the University Hospital in Heraklion, Crete, in Greece. The ossification of the medial clavicular epiphysis was classified according to Schmeling et al.
View Article and Find Full Text PDFPLoS One
January 2025
School of Hydraulic and Electric Power, Heilongjiang University, Harbin, Heilongjiang, China.
Soil moisture is the core of the hydrological cycle in agroecosystems, and most of the studies on soil moisture dynamics modeling adopt deterministic research methods, which are not well suited to study the hydrological processes in agricultural fields under changing conditions. Therefore, the present study adopts a stochastic approach to reveal the distribution characteristics of soil moisture in agroecosystems under the effects of soil, climate, vegetation, and other influencing factors. Using soil moisture and precipitation data and based on a stochastic model of soil moisture dynamics, the point-scale soil moisture dynamic characteristics and soil moisture probability density function of farmland systems in the Songnen Plain region were investigated.
View Article and Find Full Text PDFJ Epidemiol Glob Health
January 2025
Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University, No.7, Chung Shan S. Rd., Zhongzheng District, Taipei City, 100225, Taiwan.
Background: Lipids are known to be involved in carcinogenesis, but the associations between lipid profiles and different lung cancer histological classifications remain unknown.
Methods: Individuals who participated in national adult health surveillance from 2012 to 2018 were included. For patients who developed lung cancer during follow-up, a 1:2 control group of nonlung cancer participants was selected after matching.
Langmuir
January 2025
Center for Condensed Matter Theory, Department of Physics, Indian Institute of Science (IISc), Bangalore 560012, India.
The enduring pathogenicity of can be attributed to its lipid-rich cell wall, with mycolic acids (MAs) being a significant constituent. Different MAs' fluidity and structural adaptability within the bacterial cell envelope significantly influence their physicochemical properties, operational capabilities, and pathogenic potential. Therefore, an accurate conformational representation of various MAs in aqueous media can provide insights into their potential role within the intricate structure of the bacterial cell wall.
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