[Immune system reactivity in patients with chronic hepatitis c].

Aim: To determine levels of IL-1beta, IL-2, IL-4, IL-6, TNF-alpha, IFN-alpha, IFN-gamma in patients with chronic hepatitis C (CHC).

Material And Methods: Peripheral blood cytokines were measured with enzyme immunoassay (Protein contour kits, St-Petersburg).

Results: Higher content of IL-2, IFNa, IFNg was found in older patients with negative results of examination for HCV RNA, a/HCVcore IgM, a/HCV/ns3,5, genotype 3a, evidencing for higher reactivity of the immune system. High levels of IL-1beta, IL-6, TNFa were detected in young patients with narcotic drug consumption history, with high enxymatic activity, biliary inflammation, genotype 1b, high index of histological activity.

Conclusion: The above changes characterize the severity of morphological, necrotic-inflammatory changes in the liver.