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A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer.
Cancer Cell
January 2025
Cancer Systems Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK; Centre for Cancer Evolution, Bart's Cancer Institute, Queen Mary University London, London EC1M 6AU, UK. Electronic address:
Fewer than 50% of metastatic deficient mismatch repair (dMMR) colorectal cancer (CRC) patients respond to immune checkpoint inhibition (ICI). Identifying and expanding this patient population remains a pressing clinical need. Here, we report that an interferon-high immunophenotype locally enriched in cytotoxic lymphocytes and antigen-presenting macrophages is required for response.
View Article and Find Full Text PDFCultural Effects on the Performance of Older Haitian Immigrants on Timed Cognitive Tests.
Med Res Arch
November 2024
Department of Electrical Engineering and Computer Science, Florida Atlantic University, 777 Glades Road, EE 428 & 526, Boca Raton, FL, 33431.
Background: Ignoring the cultural factors that can affect performance on cognitive tests may result in use of tests that have not been validated for that group. One example is testing of Haitian Creole speaking adults who are increasingly affected by Alzheimer's disease and related dementias, for whom few tests have been validated.
Aims: Our purpose is to describe differences in timed test performance between Haitian Creole and English-speaking participants and explore factors that may account for any differences in results found.
Torsion-Induced Traumatic Optic Neuropathy (TITON): A physiologically relevant animal model of traumatic optic neuropathy.
PLoS One
January 2025
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States of America.
Traumatic optic neuropathy (TON) is a common cause of irreversible blindness following head injury. TON is characterized by axon damage in the optic nerve followed by retinal ganglion cell death in the days and weeks following injury. At present, no therapeutic or surgical approach has been found to offer any benefit beyond observation alone.
View Article and Find Full Text PDFAzSLD: Azerbaijani sign language dataset for fingerspelling, word, and sentence translation with baseline software.
Data Brief
February 2025
ADA University, Baku, Azerbaijan.
Advancements in sign language processing technology hinge on the availability of extensive, reliable datasets, comprehensive instructions, and adherence to ethical guidelines. To facilitate progress in gesture recognition and translation systems and to support the Azerbaijani sign language community we present the Azerbaijani Sign Language Dataset (AzSLD). This comprehensive dataset was collected from a diverse group of sign language users, encompassing a range of linguistic parameters.
View Article and Find Full Text PDFThe Role of Morphological Information in Processing Pseudo-words in Italian L2 Learners: It's a Matter of Experience.
J Cogn
January 2025
Department of Humanities, University of Trento, via Tommaso Gar 14, 38122, Trento, Italy.
The productive use of morphological information is considered one of the possible ways in which speakers of a language understand and learn unknown words. In the present study we investigate if, and how, also adult L2 learners exploit morphological information to process unknown words by analyzing the impact of language proficiency in the processing of novel derivations. Italian L2 learners, divided into three proficiency groups, participated in a lexical decision where pseudo-words could embed existing stems (e.
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