The aim of this study was to elucidate whether in patients with heart failure (HF) serum uric acid (UA) levels correlated with left ventricular ejection fraction (LVEF) and systolic pulmonary artery pressure (SPAP). Fifty consecutive patients with heart failure underwent serum (UA) determination and echocardiographic examination, with measurement of LVEF and SPAP. Twenty healthy age-matched subjects served as controls. Mean serum UA in patients with HF were significantly higher that in controls (7.5 +/- 0.3 vs 4.5 +/- 0.3 mg/dl, P < 0.0001). In patients group serum UA correlated negatively with LVEF (R = -0.45, P < 0.01) and positively with SPAP (R = 0.51, P < 0.001); these relations persist in a multivariable regression analysis, after adjustment for other variables potentially confounding (P = 0.031 and P = 0.003, respectively). In patients with HF, serum UA correlates with LVEF and SPAP independently from other clinical determinants, supporting the possibility that the detection of progressive hyperuricemia in these patients may be an indicator of deteriorating cardiac function.
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