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Copy Number Variation in Asthma: An Integrative Review.
Clin Rev Allergy Immunol
January 2025
Postgraduate Program in Biochemistry, Federal University of Espírito Santo (UFES), Vitória, Espírito Santo, Brazil.
Asthma is a complex disease with varied clinical manifestations resulting from the interaction between environmental and genetic factors. While chronic airway inflammation and hyperresponsiveness are central features, the etiology of asthma is multifaceted, leading to a diversity of phenotypes and endotypes. Although most research into the genetics of asthma focused on the analysis of single nucleotide polymorphisms (SNPs), studies highlight the importance of structural variations, such as copy number variations (CNVs), in the inheritance of complex characteristics, but their role has not yet been fully elucidated in asthma.
View Article and Find Full Text PDFDesign and fabrication of xylan-graft-poly (methyl methacrylate) thermoplastic via SARA ATRP.
Int J Biol Macromol
January 2025
Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China; State Key Laboratory of Efficient Production of Forest Resources, Beijing Forestry University, Beijing 100083, China. Electronic address:
Due to the emphasis on the environmental and health issues caused by petroleum-based plastics, renewable lignocellulosic materials emerge as promising substitutes. However, their practical application remains hindered by unsatisfactory properties such as fragility and sensitivity to water. Dealing with the challenge of non-thermal processing of xylan and addressing the issue of performance degradation resulting from the hygroscopicity of materials.
View Article and Find Full Text PDFLong-range directional growth of neurites induced by magnetic forces.
Acta Biomater
January 2025
School of Life Sciences, Keele University, Staffordshire, UK. Electronic address:
The ability to control the growth and orientation of neurites over long distances has significant implications for regenerative therapies and the development of physiologically relevant brain tissue models. In this study, the forces generated on magnetic nanoparticles internalised within intracellular endosomes are used to direct the orientation of neuronal outgrowth in cell cultures. Following differentiation, neurite orientation was observed after 3 days application of magnetic forces to human neuroblastoma (SH-SY5Y) cells, and after 4 days application to rat cortical primary neurons.
View Article and Find Full Text PDFPreliminary study of gunshot residues in entry holes at different angles: Feasibility of using LIBS to support trajectory estimation.
Forensic Sci Int
December 2024
Ballistics Section of the Spanish Scientific Police Headquarters (National Police), Julián González Segador s/n, Madrid, Spain; Instituto Universitario de Investigación en Ciencias Policiales (IUICP), Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Firearm-related scenarios can be highly complex, involving multiple shooters, firearms, types of ammunition, victims, and various impact zones. Obtaining the maximum amount of information to connect each piece of the puzzle is crucial for resolving these cases. Currently, new tools are being developed in the forensic field that facilitate both fieldwork and laboratory analysis, enabling the estimation of trajectories, identification of shooters, and more.
View Article and Find Full Text PDFEvaluation of the low energy cyclotron production of the gamma emitters Cd and Cd.
Appl Radiat Isot
December 2024
National Centre for Physics, Quaid-i-Azam University Campus Islamabad, Pakistan.
Cd (T = 6.5 h) and Cd (T = 461.9 d) are promising non-standard gamma-emitting radionuclides with significant potential for SPECT use.
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