[Immunohistochemistry of matrix metalloproteinases in different morphologic types of the lung cancer developed in the inhabitants of the Semipalatinsk Region].

The immunohistochemical characteristics of matrix metalloproteinases and their association with angiogenesis in different histological types of the lung cancer developed in the inhabitants of the Semipalatinsk Region (Kazakhstan) were investigated. The surgical and biopsy specimens from 87 patients with lung cancer, including 33 patients who had lived near the Semipalatinsk polygon from childhood to 2002 year and had been long exposed to radiation (annual radiation dose had been more than 0.1 Rem), were examined. Fifty-four control patients had lived in other Kazakhstan regions with the unchanged ionizing radiation background (n = 14) and in Moscow (n = 40). MMP-1, MMP-2, MMP-9, TIMP-1, VEGF, CD34, chromogranin, and CD68 were immunohistochemically detected. The increased expression of MMP-1, MMP-2, and MMP-9 in the cancer cells was ascertained in the study group as compared with the control one. Angiogenesis in the stroma of Semipalatinsk lung cancer was generally more pronounced, as judged by the expression of VEGF and the density of newly formed vessels.