AI Article Synopsis
- The presence of HHV-7 and dual HHV-6A and -6B DNA in the cerebrospinal fluid (CSF) of two patients with facial palsy (FP) raises questions but does not establish a clear cause for the condition.
- Despite analyzing samples from 33 FP patients and 36 controls, only 10% of tested CSF samples from immunocompetent individuals contained HHV DNA, which is unusual.
- Further research is needed to understand the significance of these herpesvirus findings and their relationship to FP and other diseases.
Article Abstract
Conclusions: Finding human herpesvirus (HHV)-7 and dual HHV-6A and -6B DNA in cerebrospinal fluid (CSF) of two facial palsy (FP) patients is intriguing but does not allow etiologic conclusions as such. HHV-6 or -7 DNA was revealed in 10% of the CSF samples tested from 70 immunocompetent adolescents and adults; a highly unusual result. How these findings are associated with the diseases they accompany remains to be defined.
Objective: To determine whether herpes simplex virus (HSV)-1 and -2, varicella-zoster virus (VZV), HHV-6A, -6B, and -7, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) DNA could be found in CSF of FP patients or controls.
Subjects And Methods: In all, 33 peripheral FP patients (26 idiopathic, 5 with herpesvirus infection, 1 puerperal, 1 Melkersson-Rosenthal syndrome) (34 CSF samples) and 36 controls (16 nonidiopathic FP, 7 hearing loss, 6 vertigo, 5 headache, 2 other) previously tested for HSV-1, VZV, and HHV-6 DNA by polymerase chain reaction (PCR) were tested with highly sensitive multiplex-PCR and an oligonucleotide microarray method.
Results: One FP patient had HHV-7 DNA and another had HHV-6A and -6B DNA simultaneously. In the control group, one HHV-7, one HHV-6A, and three HHV-6B DNA-positive specimens were found.
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| http://dx.doi.org/10.1080/00016480701774990 | DOI Listing |
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