AI Article Synopsis
- The study focused on the genetic and epidemic traits of influenza A (H3N2) viruses in Fujian Province, China, from 1996 to 2004, using phylogenetic analysis of HA1 gene sequences.
- Researchers found that mutations in the HA1 gene led to significant antigenic drift in the viruses over eight flu seasons, with key changes occurring at specific antibody binding sites.
- The findings suggest the importance of ongoing monitoring for mutations in HA1 to track H3 isolates as the influenza virus evolves, particularly in South Asia.
Article Abstract
We studied the genetic and epidemic characteristics of influenza A (H3N2) viruses circulated in human in Fujian Province, south of China from 1996 to 2004. Phylogenetic analysis was carried out for genes encoding hemagglutinin1 (HA1) of influenza A virus (14 new and 11 previously reported reference sequences). Our studies revealed that in the 8 flu seasons, the mutations of HA1 genes occurred from time to time, which were responsible for about four times of antigenic drift of influenza H3N2 viruses in Fujian, China. The data demonstrated that amino acid changes were limited to some key codons at or near antibody binding sites A through E on the HA1 molecule. The changes at the antibody binding site B or A or sialic acid receptor binding site 226 were critical for antigenic drift. But the antigenic sites might change and the key codons for antigenic drift might change as influenza viruses evolve. It seems important to monitor new H3 isolates for mutations in the positively selected codons of HA1 gene in south of Asia.
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| http://dx.doi.org/10.1007/s11427-008-0050-8 | DOI Listing |
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