Objective: The present study was aimed at establishing delay in diagnosing tuberculosis and associated factors.
Methods: This was a cross-sectional study. Adults from the city of Bucaramanga proving smear-positive for tuberculosis were interviewed for establishing demographic and social variables; the onset of symptoms, the date of their first visit to a doctor and time of diagnosis were established. Delay was defined as being any time longer than the mathematical average interval for such attention. Patient delay was taken as being from the onset of symptoms to the first visit to a doctor. Health service delay consisted of the time taken from first visit to diagnosis. Total delay was regarded as being from the onset of symptoms until diagnosis. Odds ratios (OR) were calculated and association between delay and risk factors was evaluated by using logistical regression.
Results: Two hundred and sixteen patients were interviewed; 131 (61 %) were males and mean age was 43. Patient delay was longer than 30 days; it was associated with unemployment (2.56 OR; 1.28-4.76 95 %CI) and the absence of social security (2.32 OR; 1.20-4.50 95 % CI). Health service delay was greater than 60 days and was associated with the contributive social security regime (1.91 OR; 1.07-3.44 95 % CI) and displacement (0.20 OR; 0.06-0.67 95 % CI). Total delay was greater than 120 days and was associated with patients lacking social security (3.54 OR; 2.25-10.8 95 % CI).
Conclusion: Average delay time for diagnosing pulmonary tuberculosis was 120 days. This was higher than in other studies which have reported delay as being 42 to 119 days. We recommend expediting the diagnosis of pulmonary tuberculosis so that other people do not become infected and improving health service commitment.
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http://dx.doi.org/10.1590/s0124-00642008000100009 | DOI Listing |
Tuberculosis (Edinb)
January 2025
CSIR-Central Drug Research Institute, Lucknow, 226031, UP, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, UP, India. Electronic address:
The limitations of existing mouse models of lung infection with Mycobacteroides abscessus impede drug discovery and development. In contrast to current animal models that introduce NTM intravenously or by intranasal/intra-tracheal instillation or via bronchoscopy-guided insufflation, we developed a dry powder inhalation (DPI) of M. abscessus ATCC 19977 that generated paucibacillary lung infection and histopathology in immunocompetent mice.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
January 2025
Henan Provincial Chest Hospital tuberculosis within Six/Critical Illness Area, Henan Infectious Diseases(TB)Clinical Research Center, Zhengzhou, Henan, 450001, PR China. Electronic address:
Purpose: This study aims to evaluate the clinical diagnostic value of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for tuberculosis and drug-resistant tuberculosis.
Patients And Methods: Totally 201 pulmonary tuberculosis patients were recruited retrospectively. All patients underwent smear microscopy, Mycobacterium growth indicator tube (MGIT) 960 culture, loop-mediated isothermal amplification (LAMP) molecular testing, Xpert MTB/RIF (Xpert), and MassARRAY assay which is a MALDI-TOF MS based method.
NEJM AI
October 2024
Google, Mountain View, CA, USA.
Background: Using artificial intelligence (AI) to interpret chest X-rays (CXRs) could support accessible triage tests for active pulmonary tuberculosis (TB) in resource-constrained settings.
Methods: The performance of two cloud-based CXR AI systems - one to detect TB and the other to detect CXR abnormalities - in a population with a high TB and human immunodeficiency virus (HIV) burden was evaluated. We recruited 1978 adults who had TB symptoms, were close contacts of known TB patients, or were newly diagnosed with HIV at three clinical sites.
Indian J Thorac Cardiovasc Surg
February 2025
Sechenov First Moscow State Medical University, Moscow, Russia.
Pulmonary arteriovenous malformation (PAVM) is a congenital vascular pathology, which is caused by the presence of a direct connection between the branches of the artery and the veins of the lungs, and the discharge of unoxygenated blood into the arterial bed. Arteriovenous malformations are characterized by a wide variety of clinical manifestations and, in some cases, may be accompanied with severe circulatory disorders.
View Article and Find Full Text PDFPLoS One
January 2025
Information Technology Section, Changshu Center for Disease Control and Prevention, Changshu, Jiangsu, China.
Objective: This study aimed to enhance the prevention and control of pulmonary tuberculosis (PTB) and provide more effective and accurate methods in Changshu City.
Methods: The PTB patients' information came from the China Information System for Disease Control and Prevention (CISDCP). The demographic data for Changshu city and towns came from the Suzhou Statistical Yearbook and the LandScan platform.
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