Total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, from a microorganism.

Chem Commun (Camb)

Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.

Published: April 2008

The first total synthesis of spiruchostatin B, a potent histone deacetylase inhibitor, was achieved in a convergent manner; the synthesis established stereochemistry at the C5'' position.

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Source
http://dx.doi.org/10.1039/b718310kDOI Listing

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