Objective: To explore the clinical significance of CP2, CA125, salicylic acid (SA) and carcinoembryonic antigen (CEA) in endometrial carcinoma patients.
Methods: A retrospective study was carried out on 154 cases of endometrial carcinoma with tumor markers test results who were admitted to our department from Aug 1992 to Nov 2004.
Results: The patients were followed up for (38+/-28) months. 23.4%, 36.8%, 19.0% and 30.3% of cases were with abnormal values of CP2, SA, CA125 and CEA. CP2 abnormal level was related with the stage, cell differentiation, adnexa metastasis, positive peritoneal cytology and pelvic lymph node metastasis (P=0.002, P=0.040, P=0.019, P=0.019, P=0.005). SA abnormal level was related with the adnexa metastasis and positive peritoneal cytology (P=0.021, P=0.000). CA125 abnormal level was related with the cell differentiation, cervical metastasis and pelvic lymph node metastasis (P=0.014, P=0.006, P=0.018). The survival was related with CP2, CA125 and CEA (P=0.016, P=0.000, P=0.016), especially CA125.
Conclusions: Among the commonly used tumor markers, CP2 is related with many clinical pathological parameters. CA125 elevation may strongly suggest worse prognosis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Evaluation of whether serum tumor markers in patients with epithelial ovarian carcinoma change following chemotherapy.
Chin Med J (Engl)
February 2012
Department of Gynecology, Peking University People's Hospital, Beijing 100044, China.
Background: Phenotypic and genotypic heterogeneity is a known feature of many cancers. Whether serum tumor marker kinds vary and change following chemotherapy is still unclear. The aim of this study was to investigate whether there is a change in the expression of serum tumor markers following chemotherapy, and the potential clinical significance in patients with epithelial ovarian carcinoma (EOC) or primary serous peritoneal carcinoma (PSPC).
View Article and Find Full Text PDFIn Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer.
BMC Syst Biol
September 2011
Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia.
Background: Our study focuses on identifying potential biomarkers for diagnosis and early detection of ovarian cancer (OC) through the study of transcription regulation of genes affected by estrogen hormone.
Results: The results are based on a set of 323 experimentally validated OC-associated genes compiled from several databases, and their subset controlled by estrogen. For these two gene sets we computationally determined transcription factors (TFs) that putatively regulate transcription initiation.
[Value of (18)F-FDG imaging and serum tumor markers in the diagnosis of recurrent endometrial carcinoma].
Zhonghua Zhong Liu Za Zhi
April 2010
Department of Nuclear Medicine, Peking University People's Hospital, Beijing 100044, China.
Objective: Both (18)F-fluorodeoxyglucose (FDG) imaging and serum tumor marker measurements can be used in the post-therapy surveillance of recurrent endometrial carcinoma, but the relationship between those two methods has not been demonstrated yet. The purpose of this study was to compare the diagnostic efficiency of (18)F-FDG imaging and serum tumor marker measurements in the diagnosis of recurrent endometrial carcinoma, as well as to analyze the correlation between those two methods.
Methods: Thirty-five patients with histopathologically confirmed endometrial carcinoma and suspected to have recurrent disease during post-therapy surveillance were included in this study.
[Profiling of serum tumor markers in patients with epithelial ovarian carcinoma].
Zhonghua Fu Chan Ke Za Zhi
February 2009
Department of Gynecology, Peking University People's Hospital, Beijing 100044, China.
Objective: To investigate whether the change of serum tumor markers profile after chemotherapy in epithelial ovarian carcinoma and evaluate the clinical significance.
Methods: The levels of CA(125), CA(19-9) and CP2 before and after initial surgery, during primary chemotherapy and follow-up were serially measured and analyzed retrospectively in 28 cases of recurrent epithelial ovarian carcinoma patients and 20 cases of primary chemo-resistant ovarian carcinoma patients from Jan 1999 to July 2007. According to whether the change of serum tumor markers profile, all the patients were divided into two groups: marker changed-group and marker un-changed group.
[Clinical significance of serum CP2, CA125, salicylic acid and carcinoembryonic antigen in endometrial carcinoma].
Zhonghua Fu Chan Ke Za Zhi
January 2008
Department of Gynecologic, Peking University People's Hospital, Beijing 100044, China.
Objective: To explore the clinical significance of CP2, CA125, salicylic acid (SA) and carcinoembryonic antigen (CEA) in endometrial carcinoma patients.
Methods: A retrospective study was carried out on 154 cases of endometrial carcinoma with tumor markers test results who were admitted to our department from Aug 1992 to Nov 2004.
Results: The patients were followed up for (38+/-28) months.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!