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Neuropsychiatric manifestations of sarcoidosis.
Ann Med
December 2025
Cardiac, Thoracic and Vascular, Sciences and Public Health, University of Padova School of Medicine and Surgery, Padua, Italy.
Background: There has been significant progress in understanding neurosarcoidosis (NS) as a distinct disorder, which encompasses a heterogeneous group of clinical and radiological alterations which can affect patients with systemic sarcoidosis or manifest isolated.
Rationale And Aim Of The Study: The healthcare challenges posed by NS and sarcoidosis in general extend beyond their physical symptoms and can include a variety of psychosocial factors, therefore the recognition of main neuropsychiatric symptoms can be useful to approach patients with NS. Methods: For this purpose, databases such as Pubmed, Medline and Pubmed Central (PMC) have been searched.
[Surgical treatment of secondary trigeminal neuralgia].
Zh Nevrol Psikhiatr Im S S Korsakova
December 2024
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency, Moscow, Russia.
Objective: To present a case series analysis of surgical treatment of patients with secondary trigeminal neuralgia.
Material And Methods: The treatment of 8 patients with secondary trigeminal neuralgia who underwent surgery since 2021 was analyzed. All records, neuroimaging archive, and follow-up observations were reviewed.
Neurosarcoidosis Masquerading as Spinal Stenosis.
Diagnostics (Basel)
October 2024
Rheumatology Unit, Carmel Medical Center, Haifa 3436212, Israel.
Article Synopsis
- A 65-year-old woman experienced progressive pain, weakness in limbs, and urinary incontinence, leading to a hospitalization for evaluation of a suspected demyelinating disease.
- MRI showed spinal cord compression due to complex disc issues and localized enhancement, prompting further tests to rule out infections and malignancies.
- The patient was ultimately diagnosed with both neurosarcoidosis and spondylotic myelopathy, and after treatment, she showed significant clinical and radiographic improvement.
A Comprehensive Characterization of Patients with Spinal Cord Neurosarcoidosis: A Single Center Cross-Sectional Study of Clinical Outcomes.
J Clin Med
August 2024
Department of Neurology, Henry Ford Health, Detroit, MI 48202, USA.
Article Synopsis
- The study aimed to analyze the clinical features, radiological outcomes, treatments, and long-term follow-up of patients diagnosed with spinal cord neurosarcoidosis over a 25-year period at a single medical center.
- A total of 39 patients were reviewed, with most showing extensive intramedullary lesions and common symptoms like neuropathic pain and weakness, leading to a prevalent use of corticosteroids and methotrexate for treatment.
- Follow-up MRI results indicated improvements over time, with a notable percentage of patients experiencing complete resolution of MRI enhancements, highlighting the need for better diagnostic clarity and treatment guidelines due to the complexity of the condition.
Systemic Sarcoidosis With Neurosarcoidosis Features as a Risk Factor for Multifocal Osteonecrosis.
Cureus
August 2024
Rheumatology, University of Maryland School of Medicine, Baltimore, USA.
Sarcoidosis is a systemic inflammatory disease that affects diverse organs such as the lungs, skin, eyes, and brain. Osseous involvement in sarcoidosis usually affects bones of the appendages with direct infiltration of non-caseating granulomas without bony infarcts. Symptoms of sarcoid bone lesions respond well to corticosteroid therapy.
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