AI Article Synopsis
- The study investigates how lead (Pb2+) affects calcium release activated calcium influx (CRACI) in human osteoblast-like cells, highlighting bone's role in lead toxicity.
- Pb2+ was found to inhibit CRACI initiation in a dose-dependent way while simultaneously increasing the influx of Pb2+ into the cells.
- The research reveals that lead's interference with CRACI functions on two levels: it partially inhibits the start of CRACI and enhances the entry of Pb2+ once CRACI is activated.
Article Abstract
To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). Pb2+ inhibited the immediate CRACI dose-dependent manner. Influx of Pb2+ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of Pb2+ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of Ca2+ upon Ca2+ readdition, is partially inhibited by Pb2+ and (2) the influx of Pb2+ was enhanced after CRACI had been induced.
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| http://dx.doi.org/10.1007/s12272-001-1140-3 | DOI Listing |
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