The purpose of this trial is to evaluate the results of musculoskeletal tumors which is treated with limb salvage surgery and extracorporeal radiotherapy. Patients were treated with en-bloc resection followed by 50 Gy single dose extracorporeal irradiation and re-implantation of involved bone segments. Nine of fifteen were female and 6 were male, median age was 19. Tumor originated from tibia in 7 patients, femur in 3, humerus in 3, calcaneus in 1 and scapula in 1. Preoperative chemotherapy was given to 12 patients, 3 of them had not been treated previously. Median follow-up time of the survivors was 22 months (range 2-47 months); local recurrence and lung metastases occurred in one patient (local recurrence was away from the re-implanted bone segment), and lung metastases were reported in another 3 patients. Wound healing problems occurred in 4 patients and delayed union in 2 patients. Amputation was performed in 2 patients due to uncontrolled infection, and infected bone was replaced by a fibula graft in another patient. Treatment was successful in 12 patients where functional results were good in 9, excellent in 2 and not evaluated in 1. Limb salvage using en-bloc resection followed by intraoperative extracorporeal irradiation and re-implantation of involved bone is a useful and cheap reconstruction method in appropriately selected patients.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Thyroid-Targeted Nano-Bombs Empower HIFU for Graves' Disease.
Adv Sci (Weinh)
January 2025
The Department of Head and Neck Surgery, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, P. R. China.
Graves' disease (GD) is an autoimmune disorder with a high incidence rate, particularly affecting women of reproductive age. Current treatment modalities for GD carry significant disadvantages, especially for pregnant or nursing women. As a novel extracorporeal therapeutic technique, high-intensity focused ultrasound (HIFU) shows great promise for treating GD; however, its low treatment efficacy impedes clinical application.
View Article and Find Full Text PDFAntitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid.
Sci Rep
January 2025
Research Division, JIMRO Co., Ltd., Takasaki, Japan.
This study investigated whether intravenous administration of tumor cells killed by photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) had antitumor effects on distal tumors. Furthermore, a novel extracorporeal blood circulating 5-ALA/PDT system was developed. 5-ALA/PDT- (low or high irradiation) or anticancer drug-treated cells were intravenously administered to rats in a glioma cancer model.
View Article and Find Full Text PDF[Decolonization of autologous blood with cefuroxime during hardware reinfusion in neurosurgical patients].
Zh Vopr Neirokhir Im N N Burdenko
December 2024
Burdenko Neurosurgical Center, Moscow, Russia.
Article Synopsis
- Autologous blood obtained during surgical hardware reinfusion is often contaminated with bacteria, predominantly from skin microflora, in up to 90% of cases, posing a risk for infection.
- Adding cefuroxime to the blood collection process was found to eliminate bacterial growth in 100% of instances when administered initially.
- Despite various decontamination methods, including washing and leukocyte filtration, some bacterial contamination remained, though the combination of these techniques with cefuroxime significantly reduced the risk of bacterial presence in processed blood samples.
Successful surgical treatment for primary cardiac angiosarcoma: a case report.
Gen Thorac Cardiovasc Surg Cases
November 2023
Department of Radiotherapy, Takarazuka City Hospital, Hyogo, Japan.
Background: Primary cardiac angiosarcomas are extremely rare and their prognosis is poor. Surgical resection is the first-line treatment; however, no clear standard of care has been clearly established because of the rarity of these tumors.
Case Presentation: A 61-year-old man who had presented with dyspnea on exertion was referred to our hospital.
Comparison of high intensity laser therapy and extracorporeal shock wave in treatment of lateral epicondylitis: a randomized controlled study.
Lasers Med Sci
November 2024
Department of Physical Therapy and Rehabilitation, Üniversiteler Mahallesi, Ankara Bilkent City Hospital, Ankara, Çankaya, 06800, Turkey.
Article Synopsis
- The study compares the short-term effects of high-intensity laser therapy (HILT) and focused extracorporeal shockwave therapy (ESWT) on pain, sensitivity, handgrip strength, and function in treating lateral epicondylitis (LE) in 47 patients.
- Participants were divided into two groups, receiving either HILT or ESWT three times a week for three weeks, along with exercises, and assessed using various measurement tools before, one week, and six weeks post-treatment.
- Both treatments showed significant improvement in pain and functionality, but there were no significant differences between the groups in efficacy, indicating that both methods are effective and safe for short-term management of LE.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!