The paper presents the results of studying the trace element status in residents from various goiter-endemic areas of the Arkhangelsk Region. It is concluded that endemic goiter in the study areas is determined by not only iodine deficiency, but also by the imbalance of thyroid-specific elements. Goiter endemic is caused by the decreased content of Se, Co, Cr, Fe, and the elevated level of Si. Moreover, an iodine-sufficient area is characterized by the lower levels of Ca, Mg, and Mn. Trace element imbalance is accounted for by the biogeochemical features of the areas under study.

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