AI Article Synopsis
- The study explores the reactions between bis(cyclopentadienyl)titanium(IV) dichloride and a new class of thiosemicarbazones derived from isatin and N(4)-substituted thiosemicarbazides, resulting in the formation of [Cp(2)Ti(L)] products.
- Various physico-chemical and spectral analyses indicate that these derivatives adopt five-coordinate structures.
- Toxicity tests reveal that some titanocene complexes significantly affect the activity of the acetylcholinesterase enzyme in the snail Lymnaea acuminata, suggesting possible enzyme-inhibitor complex formation.
Article Abstract
The reactions of bis(cyclopentadienyl)titanium(IV) dichloride with a new class of thiosemicarbazone (LH(2)), derived by condensing isatin with different N(4)-substituted thiosemicarbazides, have been studied and products of type [Cp(2)Ti(L)] have been isolated. On the basis of various physico-chemical and spectral studies, five coordinate structures have been assigned to these derivatives. Toxicity studies of titanocene complexes at tbur different concentrations have been carried out against snail Lymnaea acuminata. The effect of most potent compounds on the activity of acetylcholinesterase enzyme, which inhibits the activity of enzyme, possibly by the formation of enzyme-inhibitor complex, was also studied.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267095 | PMC |
| http://dx.doi.org/10.1155/BCA.2005.151 | DOI Listing |
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