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Predicting Plaque Regression Based on Plaque Characteristics Identified by Optical Coherence Tomography: A Retrospective Study.
Photodiagnosis Photodyn Ther
January 2025
Department of Cardiology, Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Nanjing 211166, China; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address:
Background: Atherosclerosis is a lipid-driven, systemic immune-inflammatory disease characterized by the accumulation of plaque within the arterial walls. Plaque regression can occur following appropriate treatment interventions. Optical coherence tomography (OCT), a high-resolution imaging modality, is frequently employed to assess plaque morphology.
View Article and Find Full Text PDFResearch progress on the pathogenesis of psoriasis and its small molecule inhibitors.
Arch Pharm (Weinheim)
January 2025
Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.
Psoriasis is a prevalent chronic systemic immune disease characterized by T-cellmediated hyperproliferation of keratinized cells. Among its various manifestations, plaque-type psoriasis is the most common. Treatment options for psoriasis encompass topical medications, biological therapies, phototherapy techniques, and others.
View Article and Find Full Text PDFClinical Utility of Various Formulations of Calcipotriene and Betamethasone Dipropionate for the Treatment of Plaque Psoriasis in Patients Aged 12 Years or Older.
Drug Des Devel Ther
December 2024
Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, 35-055, Poland.
Plaque-type psoriasis is a chronic immune-mediated inflammatory skin disease of uncertain etiology, significantly impacting patient well-being. This chronic condition not only contributes to stigmatization and mental health challenges but also poses an independent risk for cardiovascular and other comorbid diseases. Affecting approximately 60 million people globally, psoriasis manifests primarily as mild-to-moderate disease in about 80% of cases, where topical therapy is pivotal.
View Article and Find Full Text PDFPatient-Level Pericoronary Adipose Tissue Mean Attenuation: Associations with Plaque Characteristics.
J Cardiovasc Dev Dis
November 2024
Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark.
Article Synopsis
- - The study explores the role of pericoronary adipose tissue attenuation (PCAT) as a potential marker of inflammation in coronary artery disease by analyzing data from 466 patients who underwent coronary CT angiography (CCTA).
- - Findings revealed that PCAT measurements varied significantly between calcified and soft plaques, showing a positive association with total and non-calcified plaque burdens, while being negatively linked to calcified plaque burden.
- - The research concluded that PCAT had a more pronounced effect on plaque characteristics in the absence of different plaque types, indicating its potential importance in understanding coronary artery disease progression.
Phosphatidylserine Topically Attenuates Imiquimod-induced Psoriasis Through Inflammation Inhibition in Mice.
Drug Res (Stuttg)
January 2025
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Background: Psoriasis is a chronic skin condition that is associated with persistent inflammation and skin lesions. Topical therapy has been a promising approach to the alleviation of psoriasis through the application of anti-inflammatory agents. Phosphatidylserine (PS) administration has shown anti-inflammatory effects in the trials.
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