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Efficacy of Preemptive Topical Lidocaine 5% Plaster in the Prevention of Post-Craniotomy Pain, a Randomized Clinical Trial.
J Pain Res
December 2024
Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People's Republic of China.
Objective: The current landscape is characterized by a dearth of effective, safe, simple, and noninvasive methods for preventing pain following craniotomy. This clinical trial seeks to evaluate the efficacy profile of preemptive application of a topical 5% lidocaine patch in alleviating post-craniotomy pain.
Methods: This was a multi-centric, prospective randomized placebo-controlled triple-blind clinical trial.
Highly Water-Soluble Microneedle Patch for Short Wear Time and Rapid Drug Delivery.
Mol Pharm
December 2024
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Article Synopsis
- * The development of a new type of microneedle (MN) patch, made from a polymer/drug mix, allows for quick and painless application to the skin for both local and systemic drug delivery.
- * A specific MN patch design using polyvinylpyrrolidone (PVP) and lidocaine (L) with added sodium bicarbonate (NaB) enhances MN dissolution speed by 60%, enabling a much shorter wear time for effective pain relief.
Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review.
J Diabetes Metab Disord
December 2024
Anesthesiology Department, State University of Campinas, Campinas, Brazil.
Article Synopsis
- - The study reviewed the effectiveness of topical medications for diabetic neuropathic pain (DNP) and compared them with oral pain relief options.
- - The most promising topical treatments identified were 8% Capsaicin patches and 5% Lidocaine patches, along with evidence supporting topical clonidine, gabapentin, and amitriptyline.
- - Topical medications could be viable alternatives to oral medications for DNP, and further research is needed on combining different topical treatments for better effectiveness.
Effect of 5% lidocaine-medicated plaster in preventing chronic postsurgical pain after knee replacement: protocol for a randomized double-blind placebo-controlled trial.
Front Pharmacol
October 2024
Department of Pain Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Background: With an aging population, knee arthroplasty is increasingly common; however, chronic postsurgical pain (CPSP) affects up to 30% of patients. This study aims to evaluate the efficacy of 5% lidocaine-medicated plaster (LP5) in preventing CPSP among patients undergoing knee arthroplasty.
Methods: This is a dual-center, randomized, double-blind, placebo-controlled trial involving 128 adult patients scheduled for knee arthroplasty.
Lidocaine patches after cesarean sections: a randomized control trial.
Am J Obstet Gynecol MFM
December 2024
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT (Arkfeld, Starosta, Esencan, Athens, Lundsberg, Merriam).
Objectives: Lidocaine patches are a common topical analgesic therapy but have not been thoroughly investigated in the surgical or obstetric literature. We sought to investigate the impact of adding topical lidocaine patches to routine postcesarean pain management on patients' postcesarean pain scores and opioid use.
Study Design: This is a prospective randomized subject-blinded controlled trial of patients undergoing cesarean delivery at a single institution.
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