AI Article Synopsis
- The study aimed to investigate the presence of herpes simplex virus (HSV) in pterygia to see if there's a link between HSV and pterygium in Taiwan, where pterygium is common.
- HSV was detected in 3 out of 65 pterygia samples, but no HSV was found in normal conjunctiva or other tissue controls, suggesting the virus may not play a role in pterygium.
- The results indicate that there is no significant connection between HSV presence and pterygium formation, leaving the cause of pterygia still unclear.
Article Abstract
Purpose: To evaluate the presence of herpes simplex virus (HSV) in pterygia to study the possible association between HSV and pterygia in Taiwan, a tropical country with a high prevalence of pterygium.
Methods: Sixty-five pterygia, 10 normal conjunctiva, 8 conjunctival nevi, and 2 malignant conjunctival melanomas were obtained. Clinical histories were recorded for each patient. HSV detection was accomplished by polymerase chain reaction amplification of viral sequences. HSV-positive specimens underwent subsequent DNA in situ hybridization. Results were statistically analyzed.
Results: By using polymerase chain reaction, HSV was detected in 3 (5%) pterygia, and no conjunctival control displayed HSV. All 3 HSV-positive pterygia studies were DNA in situ hybridization negative. There was no statistically significant correlation between pterygium and the presence of HSV.
Conclusions: HSV is not associated with pterygium formation in Taiwan; the pathogenesis of pterygia is still incompletely understood.
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| http://dx.doi.org/10.1097/ICO.0b013e31815ca667 | DOI Listing |
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