A detailed biochemical characterization of the Pseudomonas aeruginosa VIM-11 metallo-beta-lactamase (MbetaL) is reported. The only substitution differentiating VIM-11 from VIM-2 (N165S) promoted a slightly improved catalytic efficiency of the former on 3 out of 12 substrates, notably the bulky cephalosporins. Thus, MbetaL-mediated resistance also may be modulated by remote mutations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2415757 | PMC |
| http://dx.doi.org/10.1128/AAC.01025-07 | DOI Listing |
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