A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. | LitMetric
Browse Categories

Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.

Vijaya Gracias Zhiqin Ji Irini Akritopoulou-Zanze Cele Abad-Zapatero Jeffrey R Huth Danying Song Philip J Hajduk Eric F Johnson Keith B Glaser Patrick A Marcotte Lori Pease Nirupama B Soni Kent D Stewart Steven K Davidsen Michael R Michaelides Stevan W Djuric

Bioorg Med Chem Lett

Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA.

Published: April 2008

We report the discovery of the pyrimido-diazepine scaffolds as novel adenine mimics. Structure-based design led to the discovery of analogs with potent inhibitory activity against receptor tyrosine kinases, such as KDR, Flt3 and c-Kit. Compound 14 exhibited low nanomolar KDR enzymatic and cellular potencies (IC(50)=9 and 52 nM, respectively).

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bmcl.2008.03.021DOI Listing

Publication Analysis

Top Keywords

receptor tyrosine
8
scaffold oriented
4
oriented synthesis
4
synthesis design
4
design synthesis
4
synthesis biological
4
biological evaluation
4
evaluation pyrimido-diazepines
4
pyrimido-diazepines receptor
4
tyrosine kinase
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

Privacy Policy Site Map

© LitMetric 2025. All rights reserved.