Cocaine-associated cues acquire incentive motivational effects that manifest as cue-elicited craving in humans and cocaine-seeking behavior in rats. Here we examine the hypothesis that neuronal processes associated with incentive motivational effects of cocaine cues involve increased expression of the plasticity-associated gene, Arc. Rats trained to self-administer cocaine subsequently underwent extinction training, during which cocaine-seeking behavior (i.e., responses without cocaine reinforcement) progressively decreased. Rats were then tested for cocaine-seeking behavior either with or without response-contingent presentations of light/tone cues that had been previously paired with cocaine infusions during self-administration training. Cues elicited reinstatement of cocaine-seeking behavior and were accompanied by increased Arc mRNA levels in the orbitofrontal, prelimbic, and anterior cingulate cortices, suggesting Arc involvement in conditioned plasticity associated with incentive motivational effects of cocaine cues. Additionally, rats with a history of cocaine self-administration and extinction exhibited upregulation of Arc expression in several limbic and cortical regions relative to saline-yoked controls regardless of cue exposure condition, suggesting persistent neuroadaptations involving Arc within these regions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832122 | PMC |
| http://dx.doi.org/10.1002/syn.20502 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Seeking under threat of adversity: assessing control over reward pursuit in rats.
Psychopharmacology (Berl)
December 2024
Department of Population Health Sciences, Unit of Animals in Science and Society, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Rationale: Substance use disorder (SUD) is a chronic relapsing brain disorder that is characterised by loss of control over substance use. A variety of rodent models employing punishment setups have been developed to assess loss of control over substance use, i.e.
View Article and Find Full Text PDFIndividual differences in prelimbic neural representation of food and cocaine seeking.
Cell Rep
December 2024
Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address:
The prelimbic cortex is involved in operant reward seeking. However, the precise nature of its activity patterns and whether/how they differ between different types of rewards are largely unknown. We use miniscope calcium imaging to observe prelimbic activity during both food and cocaine seeking in freely behaving mice.
View Article and Find Full Text PDFArticle Synopsis
- Cocaine use disorder (CUD) is a major public health issue, and there's currently no FDA-approved medication to treat it, highlighting the need for new treatments.
- RDS04-010, a novel atypical dopamine transporter inhibitor, shows promise in animal models by significantly reducing cocaine-seeking behavior without producing addictive effects, unlike its analog RDS03-094 which has more cocaine-like properties.
- The study’s results emphasize the importance of the binding conformation to the dopamine transporter and suggest RDS04-010 could be a potential therapeutic option for CUD due to its ability to lower motivation for cocaine use.
Effects of metformin on binge-like ethanol drinking and adenosine monophosphate kinase signaling in inbred high drinking in the dark line 1 mice.
Alcohol Clin Exp Res (Hoboken)
December 2024
Research and Development Service, Portland Veterans Affairs Medical Center, Portland, Oregon, USA.
Background: Adenosine monophosphate-activated protein kinase (AMPK) signaling plays a vital role in regulating cellular metabolism and energy throughout the body. Ethanol and cocaine both reduce AMPK activity in addiction-related brain regions. Though AMPK activation has been found to reduce cocaine seeking, its role in harmful drinking and alcohol use disorder (AUD) progression remains unclear.
View Article and Find Full Text PDFDelineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains.
Psychopharmacology (Berl)
November 2024
Department of Psychology, Tufts University, Medford, MA, USA.
Rationale: Anticipation is a critical antecedent to drug use, in which the prospect of imminent drug availability can potently motivate instrumental actions directed to procure it. Models that capture the behavioral dynamics that precede drug access may allow for the dissociation of key neural mechanisms underlying appetitive or consummatory processes in drug self-administration.
Objectives: We aimed to isolate measurements attributed to the procurement and consumption of a reward by defining distinct actions for each using a chain-schedule of reinforcement.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!