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Antibody Response to Respiratory Syncytial Virus Vaccination in Immunocompromised Persons.
JAMA
December 2024
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: Hallmark features of AD are well defined, however, the generation of in vitro models of sporadic AD poses a significant challenge due to the complex, undefined etiology and slow progression of this disease. Herpes simplex virus type I (HSV-1) is a pathogen that is gaining increasing attention as a potential causative agent in AD pathogenesis. HSV-1 is a DNA virus that typically resides throughout the peripheral nervous system in a latent state.
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Alzheimers Dement
December 2024
Tulane National Primate Research Center, Tulane University, Coviington, LA, USA.
Background: Varicella zoster virus (VZV) is latent in ganglionic neurons in >90% of the world population and reactivates to produce herpes zoster in older adults. Zoster increases dementia risk, of which Alzheimer's disease (AD) is the most common. However, a critical barrier in studying the mechanisms by which VZV contributes to dementia is that VZV is an exclusively human virus.
View Article and Find Full Text PDFBackground: Hyperphosphorylation and aggregation of neuronal tau protein is a primary pathological hallmark of Alzheimer's disease (AD) and primary tauopathies. The accumulation of aggregated tau as neurofibrillary tangles (NFTs) is closely correlated with neurodegeneration and cognitive decline. Key phosphorylation sites on tau have been established as early biomarkers for disease detection and prediction, with various phosphorylation sites differentially appearing across diseases and disease stages.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
The University of Texas Health Science Center at Houston, Houston, TX, USA.
Background: Alzheimer's disease (AD) is an heterogenous disorder characterized by the accumulation of amyloid-beta (Aβ) and tau. One possible explanation for the clinical and pathological variation in AD lies in the presence of distinct conformational strains of Aβ. Numerous studies provide compelling evidence for the existence of such strains as well as their ability to template their conformations in a prion-like manner.
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