Fresnel null correctors are compared with classical Offner and Hindle null correctors for both optical performance and system sensitivities to errors of construction and placement in the test setup. Fresnel null correctors are closely related to circular diffractive null correctors, the main difference being that a Fresnel uses tilted grooves functioning like a blazed diffraction grating. The Fresnel has an advantage in that specific power terms can produce an aspheric wave front directly and not as the byproduct of bending lenses as in the traditional lens null correctors. The parametric relationships are summarized for a range of configurations of lens null correctors and for Fresnel null correctors. The sensitivities to construction and deployment errors are presented for each of these examples. The performance of two Fresnel correctors for an autocollimation test of a full three-mirror Cassegrain configuration is presented.
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http://dx.doi.org/10.1364/ao.40.003688 | DOI Listing |
J Cyst Fibros
November 2024
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States. Electronic address:
Background: People with cystic fibrosis carrying two nonsense alleles lack CFTR-specific treatment. Growing evidence supports the hypothesis that nonsense mutation identity affects therapeutic response, calling for mutation-specific CF models. We describe a novel W1282X mouse model and compare it to an existing G542X mouse.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
September 2023
The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Defects in the primary cilium are associated with autosomal dominant polycystic kidney disease (ADPKD). We used a combination of animal models, Western blotting, and confocal microscopy and discovered that CFTR and polycystin 2 (PC2) are both colocalized to the cilium in normal kidneys, with the levels of both being decreased in cystic epithelia. Cilia were longer in CFTR-null mice and in cystic cells in our ADPKD animal models.
View Article and Find Full Text PDFCell Chem Biol
September 2022
Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:
The tumor suppressor p53 is the most frequently mutated protein in human cancer. The majority of these mutations are missense mutations in the DNA binding domain of p53. Restoring p53 tumor suppressor function could have a major impact on the therapy for a wide range of cancers.
View Article and Find Full Text PDFActa Pharmacol Sin
November 2022
Department of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
Neutrophil extracellular traps (NETs) play crucial roles in atherosclerotic cardiovascular diseases such as acute coronary syndrome (ACS). Our preliminary study shows that oxidized low-density lipoprotein (oxLDL)-induced NET formation is accompanied by an elevated intracellular Cl concentration ([Cl]) and reduced cystic fibrosis transmembrane conductance regulator (CFTR) expression in freshly isolated human blood neutrophils. Herein we investigated whether and how [Cl] regulated NET formation in vitro and in vivo.
View Article and Find Full Text PDFCells
January 2022
Faculty of Sciences, Biosystems & Integrative Sciences Institute (BioISI), University of Lisbon, 1749-016 Lisbon, Portugal.
Although some therapeutic progress has been achieved in developing small molecules that correct F508del-CFTR defects, the mechanism of action (MoA) of these compounds remain poorly elucidated. Here, we investigated the effects and MoA of MCG1516A, a newly developed F508del-CFTR corrector. MCG1516A effects on wild-type (WT) and F508del-CFTR were assessed by immunofluorescence microscopy, and biochemical and functional assays both in cell lines and in intestinal organoids.
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