AI Article Synopsis
- Histamine is important in allergic reactions, but its specific effect on goblet cell hyperplasia in asthma isn't fully understood.
- The study used histamine-deficient mice to analyze goblet cell responses after exposure to an allergen (ovalbumin).
- Results showed that while both types of mice experienced increased eosinophils, the histamine-deficient mice had significantly higher levels of goblet cell markers, suggesting histamine may regulate goblet cell hyperplasia in asthma.
Article Abstract
Although histamine is a central mediator in the immediate allergic reaction, its role in goblet cell hyperplasia in the airway of asthma is not completely understood. This study was designed to examine the role of histamine in goblet cell hyperplasia using histamine-deficient mice (Hdc(-/-) mice) with allergic airway inflammation. Wild-type and Hdc(-/-) C57BL/6 mice were sensitized with ovalbumin (OVA). After two-week exposure to OVA, goblet cell hyperplasia was evaluated. Cell differentials in BALF were analyzed. The mRNAs level of MUC5AC and Gob-5 gene were quantitatively determined. The number of eosinophils in BALF increased in both the wild-type mice and Hdc(-/-) mice; however, their ratio in Hdc(-/-) mice was significantly lower than that in the wild-type mice. The mRNA levels of Gob-5 and MUC5AC and the ratio of the goblet cells in the airway epithelium were significantly increased in Hdc(-/-) mice exposed to OVA compared to the wild-type mice under the same condition. These results suggested that histamine may play a regulatory role in goblet cell hyperplasia in allergic airway inflammation.
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| http://dx.doi.org/10.1254/jphs.fm0070262 | DOI Listing |
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